摘要
目的探讨糖尿病周围神经病变（diabetic peripheral neutropathy,DPN）患者糖化血红蛋白及血尿酸水平的变化及其相关因素。方法选择2011年2月~2012年2月来我院接受治疗的2型糖尿病并周围神经病变患者100例作为观察组,选择同期来我院健康体检者100例作为对照组。检测两组糖化血红蛋白、血尿酸及血糖等指标,并用多元Logistic回归分析确定上述指标与DPN发病的相关性。结果观察组患者糖化血红蛋白、血尿酸及血糖水平均较对照组升高（P〈0.05）;且观察组患者随着病情加重,糖化血红蛋白、血尿酸水平有升高趋势,组内比较,差异有统计学意义（F=15.438、16.515,P〈0.05）;多元Logistic回归分析显示,高血尿酸、高糖化血红蛋白是2型糖尿病并发周围神经病变的危险因素（P〈0.05）。结论糖化血红蛋白、血尿酸水平与DPN的发生密切相关,监测糖化血红蛋白、血尿酸水平对于改善DPN预后意义重大。
Objective To study the changes of HbA1c and uric acid（UA） levels in patients with diabetic peripheral neutropathy（DPN）,and its relevant factors.Methods 100 cases of patients with type 2 diabetes combined with peripheral neuropathy in our hospital from February 2011 to February 2012 were chosen as the observation group.100 cases with health physical examination in the same period in our hospital were chosen as the control group.The levels of UA,HbA1c,blood sugar were tested,and the correlation between these indexes and the incidence of DPN was identified by multiple Logistic regression analysis.Results Compared with the control group,the HbA1c,blood UA and blood sugar levels in the observation group increased（P 0.05）,and in the observation group the level of UA,HbA1c increased with the aggravating of illness,comparison between the groups had statistical significance（F = 15.438,16.515,P 0.05）.Multiple Logistic regression analysis showed that high UA,high HbA1c levels were risk factors in patients with type 2 diabetes combined with peripheral neuropathy（P 0.05）.Conclusion It has closely correlation between HbA1c,UA and DPN.It has great significance to improve prognosis by DPN closely monitoring HbA1c,blood UA levels.
出处
《中国医药导报》
CAS
2013年第3期59-60,63,共3页
China Medical Herald
关键词
糖尿病周围神经病变
糖化血红蛋白
血尿酸水平
2型糖尿病
血糖
Diabetic peripheral neuropathy
Glycosylated hemoglobin
Level of blood uric acid
Type 2 diabetes
Blood sugar
