摘要
目的研究SIRT1和p53在合并糖尿病子宫内膜癌的表达。方法应用免疫组化法检测实验组39例合并2型糖尿病子宫内膜癌患者、对照组40例不合并糖尿病子宫内膜癌患者及25例正常子宫内膜标本的SIRT1、p53表达情况，分析指标间相关性。结果实验组SIRT1和p53的阳性率分别为64．1％、59．0％，对照组分别为85．0％和52．5％。实验组SIRT1表达低于对照组（χ^2=4．561，P=0．033）。对照组SIRT1和p53的阳性率均高于正常子宫内膜组（χ^2=21．462，P〈0．001；χ^2=6．771，P=0．009）。SIRT1与p53的表达呈正相关（r=0．360，P=0．024）。结论在子宫内膜癌患者中，高血糖可能下调S1RT1，SIRT1可能通过抑癌基因p53的沉默作用促进子宫内膜癌的形成。
Objective To investigate the expressions and significances of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus. Methods Immunohistochemistry was carried out to examine the expressions of SIRT1 and p53 in 39 cases of endometrial carcinoma with diabetes mellitus and 40 cases of endometrial carcinoma without diabetes mellitus and 25 cases of normal endometrium, and the correlations between these indexs were analysed. Results The positive rate of SIRT1 and p53 in experimental group was 64.1% , 59.0% respectively, and 85.0% , 52.5% in control group. The positive rate of SIRT1 in experimental group was lower than that of control group （χ2 = 4. 561, P = 0.033）. The positive rates of SIRT1 and p53 in control group were higher than that of normal endometrium （ χ2 = 21. 462, P 〈 0. 001 ; χ2 = 6. 771, P = 0. 009）. Expression of SIRT1 was positively correlated witb p53 （ r = 0. 360, P = 0.024）. Conclusions Hyperglycemia deregulates SIRTI in endometrial carcinoma. SIRT1 may promote tumorigenesis by silence of p53.
出处
《国际肿瘤学杂志》
CAS
2013年第3期236-239,共4页
Journal of International Oncology
