摘要
目的探讨肺癌患者和健康人的血清样本中血管内皮生长因子-B（VEGF—B）和胎盘生长因子（PIGF）的含量，及其与分期、肿瘤的分化程度、远处转移、化疗效果等特征的相关性。方法通过酶联免疫吸附法分别检测肺癌患者化疗前后和健康对照者的血清样本中的VEGF—B、PIGF的浓度，并进行统计学处理。结果VEGF—B和PIGF在肺癌患者血清中的含量明显高于健康人群（P〈0．01），并与分期、远处转移呈正相关（P〈0．05）；与分化程度、年龄、性别、肿瘤的病理类型无关（P〉0．05）。经EP方案治疗后，肺癌患者血清中VEGF—B和PIGF的水平在治疗前后的变化与治疗效果相关（P〈0．05）。经Pearson相关性检验发现VEGFB和PIGF显著相关（r=0．514，P〈0．01）。结论VEGF—B和PIGF共同参与肺癌的发生发展、侵袭转移过程；治疗前后血清VEGF—B和PIGF含量变化可作为肺癌患者疗效预测的指标。
Objective To investigate the serum expression of vascular endothelial growth factor-B （VEGF-B） and placental growth factor （PIGF） in lung cancer patients and healthy people, and its relationship with clinical pathological features. Methods The serum expression of VEGF-B and PIGF in lung cancer patients and healthy people was tested by enzyme-linked immunosorbent assay. Results The serum expression of VEGF B and PIGF in lung cancer patients was significantly higher than that in healthy people （ P 〈0.01）,and the levels of VEGF-B and PIGF were positively correlated with stage, metastasis status （all P 〈 0.05 ）. However, there was not significantly difference on different differentiations, gender,age,tumor pathological types （all P 〉0. 05）. Also,the levels of serum VEGF-B, PIGF were correlated with treatment outcomes. Besides, there was correlation in the concentrations of serum VEGF B and PIGF in lung cancer （ r =0. 514, P 〈0.01）. Conclusions VEGF-B and PIGF may take part in the progress of lung cancer. The changes of serum VEGF-B and PIGF levels after chemotherapy might be helpful in the prediction of treatment outcomes.
出处
《国际呼吸杂志》
2013年第4期254-257,共4页
International Journal of Respiration
关键词
肺癌
血管内皮生长因子-B
胎盘生长因子
酶联免疫吸附法
Lung cancer
Vascular endothelial growth factor B
Placental growth factor
Enzymelinked immunosorbent assay
