摘要
恶性胸腔积液大多是由恶性肿瘤累及胸膜所致，它是癌症晚期常见并发症，预后差。大量胸腔积液可引起胸闷、咳嗽、呼吸困难等临床症状，严重影响患者的生活质量。该文总结了近年来对恶性胸腔积液形成机制的研究进展，包括血管内皮生长因子、免疫细胞、水通道蛋白等在恶性胸腔积液形成中的作用，为恶性胸腔积液的治疗提供新的治疗思路。
Malignant pleural effusion is mostly caused by malignant tumor involving the pleura. It is a common complication of advanced cancer, and the prognosis is poor. A large amount of pleural effusion can cause clinical symptoms such as chest tightness, cough, and dyspnea, which seriously affect the quality of life of the patients. This review summarizes recent advances in the formation mechanism of malignant pleural effusion, including the role of vascular endothelial growth factor （VEGF）, immune cells and aquaporins in the formation of malignant pleural effusion, and provides a new treatment for malignant pleural effusion.
作者
李金金
轩伟霞
张晓菊
Li Jinjin;Xuan Weixia;Zhang Xiaoju(Department of Respiratory and Critical Care Medicine, the People＇s Hospital of Zhengzhou University, Zhengzhou 450003, Chin)
出处
《国际呼吸杂志》
2018年第10期783-786,共4页
International Journal of Respiration
基金
河南省科技创新人才计划（154100510021）
河南省医学科技攻关计划普通项目（201602211）
关键词
恶性胸腔积液
血管生成
血管通透性
分子机制
免疫细胞
Malignant pleural effusion
Angiogenesis
Vasopermeability
Molecular mechanism
Immune cells
