摘要
目的检测血清几丁质酶-3样蛋白-1(YKL40)及骨桥蛋白(OPN)在子宫内膜异位症患者血清中的水平,探讨YKL40及OPN与子宫内膜异位症的相关性。方法采用酶联免疫吸附试验(ELISA)法检测45例子宫内膜异位症患者(子宫内膜异位症组)及23例对照组患者血清中YKL40及OPN的水平并进行比较。结果手术前,子宫内膜异位症组患者血清YKL40及OPN的检测水平均高于对照组,差异有统计学意义(P<0.05)。术后1周复查,子宫内膜异位症组YKL40及OPN水平降低,与手术前比较差异有统计学意义(P<0.05);对照组与术前比较差异无统计学意义(P>0.05)。术前临床分期Ⅲ、Ⅳ期患者血清YKL40水平高于Ⅰ、Ⅱ期患者,差异有统计学意义(P<0.05);而血清OPN水平Ⅲ、Ⅳ期患者与Ⅰ、Ⅱ期比较,差异无统计学意义(P>0.05)。结论 YKL40及OPN与子宫内膜异位症的发生、发展及预后密切相关,但二者无明显相关性,可能在子宫内膜异位症的发生发展中是2个独立的事件。
Objective To detect the contents of the serum chitinase-3-like protein 1（YKL40）and osteopontin（OPN）in patients with endometriosis,and to explore the relationship of YKL40 and OPN with endometriosis.Methods The serum levels of YKL40 and OPN in endometriosis group（n=45）and control group（n=45）were detected by enzyme-linked immunosorbent assay technique（ELISA）and compared between the two groups.Results Before operation,the serum contents of YKL40 and OPN in endometriosis group were significantly higher than those in control group（P0.05）.A week after operation,the serum contents of YKL40 and OPN in endometriosis group were obviously reduced,there were statistical difference compared with before operation（P0.05）;but there were no statistical difference compared with before operation in control group（P0.05）.The serum YKL40 levels in phase Ⅲ,Ⅳ patients were significantly higher than those of phaseⅠ,Ⅱpatients before surgery（P0.05）;while there were no statistical significance of serum OPN levels between phaseⅠ,Ⅱand phase Ⅲ,Ⅳ patients（P0.05）.Conclusion The YKL40 and OPN may play an important role in the occurrence and development and prognosis of endometriosis,but both unrelated.They may be two separate events in the occurrence and development of endometriosis.
出处
《新乡医学院学报》
CAS
2013年第3期227-229,共3页
Journal of Xinxiang Medical University
