摘要
目的 探讨吡哌酸锌对实验性胃溃疡的作用及作用机制。方法 健康大鼠和小鼠 ,均衡随机分为 5组 ,即阴性对照组 (羧甲基纤维素钠 )、阳性对照组 (西咪替丁 )、吡哌酸锌 2 5mg·kg-1、5 0mg·kg-1和10 0mg·kg-1剂量组 (小鼠剂量加倍 ) ,每组 10只 ,分别观察对 4种实验性胃溃疡的作用。结果 吡哌酸锌对各种胃溃疡模型的抑制率与阴性对照组相比差异显著 (P <0 .0 1) ,并呈剂量依赖性。结论 吡哌酸锌对实验性胃溃疡有保护作用。
Objective To study the effects of zinc pipemidate on experimental gastric ulcers and its mechanism.Methods Normal rats and mice were randomly dirvided into 5 groups including negative control group(sodium carboxymethyl cellulose),positive control group(cimetidine),groups of zinc pipemidate(25mg·kg -1 ,50mg·kg -1 and 100mg·kg -1 ) in rat (50mg·kg -1 ,100mg·kg -1 and 200mg·kg -1 groups in mice).Each group included 10 animals. The effects of zinc pipemidate on experimental gastric ulcers were observed . Results Zine pipemidate produced dose-dependent relationship and significance hibitory effects on gastric ulcers, compared with the control group . Conclusion Zinc pipemidate pressesses protective effects on experimental gastric ulcer.
出处
《新乡医学院学报》
CAS
2000年第4期240-241,244,共3页
Journal of Xinxiang Medical University
关键词
吡哌酸锌
实验性胃溃疡
西咪替丁
治疗
药理
zinc pipemidate
experimental gastric ulcer
cimetidine
protective effect
rat
mice
