摘要
目的:了解南京地区妇女宫颈人乳头瘤病毒(human papillomavirus,HPV)感染及亚型分布情况。方法:用核酸分子芯片快速杂交法对7 531名妇女进行宫颈脱落细胞HPV DNA基因分型检测,并对HPV感染率、亚型分布进行统计分析。结果:南京地区妇女宫颈部位HPV感染率为33.0%(年龄标准化率为37.3%);在2 485例HPV感染者中,≤24岁年龄组妇女感染率最高,为43.3%,各年龄组间HPV感染率有显著性差异;≤24岁年龄组妇女多重亚型感染率最高,为40.0%,各年龄组间的多重亚型感染率有显著性差异;在所检测出来的21种亚型中,HPV16、58、52是最常见的高危亚型,感染率分别为8.6%、7.6%、5.2%。结论:南京地区≤24岁妇女宫颈部位HPV感染率较高,应作为宫颈疾病预防的重点人群。HPV16、HPV58、HPV52是该地区妇女宫颈部位最常见的感染亚型。
Objective：To analyze the prevalence and genotype distribution of cervical human papillomavirus （HPV） infection among women in Nanjing, China. Methods：Fast nucleic acid hybridization chip was performed to detect cervical HPV DNA and genotype of 7 531 women and the prevalence and genotype distribution were analyzed. Results：The overall prevalence of cervical HPV infection was 33.0% among women in Nanjing （age-standardized prevalence was 37.3% ）. Among 2 485 HPV-positive women,the overall prevalence of HPV infection was highest in the group aged ≤24 years（43.3% ）and there was significant difference between the prevalence of different age-stratified group;the overall prevalence of multiple genotypes HPV infection was highest in the group aged ≤ 24 years（40.0%）and there was significant difference between the prevalence of different age-stratified group;among the detected 21 HPV genotypes, the most common high-risk HPV genotypes were HPV 16 （8.6%）, HPV58 （7.6%）, HPV52 （5.2%）. Conclusion：The prevalence of cervical human papillomavirus among women aged ≤24 years in Nanjing was relatively high,cervical disease prevention program should give priority to this population;HPV 16,HPV 58 and HPV 52 were the most prevalent cervical HPV genotypes among women in Nanjing.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2013年第2期206-209,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
南京医科大学科技发展基金重点项目(2011NJ-MU215)
