摘要
实验在 31只乌拉坦麻醉 ,琥珀酰胆碱肌松、人工呼吸的大鼠上进行。观察到 :臂旁核注入 γ-氨基丁酸(GABA) ,引起平均动脉压 (MAP)显著降低 (P<0 .0 0 1) ;臂旁核内注入荷包牡丹碱 (Bic)引起 MAP显著升高 (P<0 .0 0 1) ;GABA的降压效应可被臂旁核内预注射 Bic所阻断。上述药物在臂旁核均对心率无明显影响 (P>0 .0 5 )。结果表明 :GABA在臂旁核内引起降压效应 ;臂旁核的内源性 GABA具有紧张性降压作用 。
Experiments were carried out in 31 urethane anesthetized, Suxamethonium chloride paralyzed and artificially ventilated rats. The results were as follows: microinjection of γ amino butyric acid (GABA) into parabrachial nuclei (NPB) markedly decreased the mean arterial pressure (MAP)( P <0 001), while the microinjection of bicuculine (Bic) into NPB caused a significant increase in MAP ( P <0 001). The depressor effect of GABA could be blocked by preinjection of Bic in NPB. The above agents microinjected into NPB had no significant effect on heart rate ( P >0.05). The results indicated that: (1) GABA in NPB exerts tonic depressor effect; (2) Endogenous GABA in NPB exerts tonic depressor action and takes part in maintenance of normal blood pressure level.
出处
《同济医科大学学报》
CSCD
2000年第5期391-393,共3页
Acta Universitatis Medicinae Tongji
关键词
臂旁核
Γ-氨基丁酸
荷包牡丹碱
平均动脉压
心率
parabrachial nucleus
γ-amino butyric acid
bicuculine
mean arterial pressure
heart rate
