摘要
目的评价无创机械通气(NMV)联合法舒地尔在老年人慢性肺心病伴呼吸衰竭治疗中的价值。方法老年慢性肺心病伴呼吸衰竭患者60例,治疗组、常规组各30例。常规组静脉给药:呼吸兴奋剂、酚妥拉明、强心、利尿剂等,同时NMV治疗。治疗组则改用法舒地尔30 mg Q12h降肺动脉压。观察治疗72 h两组临床疗效、肺动脉收缩压力和血浆BNP变化。结果与常规组相比,治疗组总有效率(83.3%)明显增高(P<0.05)。治疗后两组肺动脉收缩压及血浆BNP水平降低,以治疗组改善显著(P<0.05或P<0.01)。结论无创通气联合法舒地尔治疗老年慢性肺心病伴呼吸衰竭在短期内改善了患者肺通气功能,同时降低了患者肺动脉收缩压及血浆BNP水平,改善了患者心功能,快速改善了患者临床症状,取得了良好疗效。
Objective To investigate the curative effects of noninvasion mechanical ventilation （NMV） combination with injec- tion of fasudil on cor pulmonale patients complicated with respiratory failure. Methods Sixty patients with cor pulmonale complicated with respiratory failure were randomly divided into treatment group and routine group. Patients in routine group （30 cases） were treated by NMV combined with routine therapy while patients in treatment group（30 cases） usage of fasudil substition for phentolamine. The clinical effica- cy was observed. The concentrations of plasma BNP and pulmonary hypertension were also measured at the beginning and 72 h later. Re- suits Treatment group had a significantly higher overall response rate83.3 %, compared with routine group （P 〈 O. 05 ）. Pulmonary sys- tolic pressure and plasma levels of BNP were significantly decreased after treatment in both groups, especially in the fusudil group （ P 〈 O. Ol ）. Conclusion Noninvasion mechanical ventilation combination with injection of fasudil can improve ventilatory function and de- crease the level of pulmonary systolic pressure and BNP improving the patient＇s heart function in short time in cor pulmonale complicated with respiratory failure highlighting the good clinical efficacy.
出处
《临床肺科杂志》
2013年第4期669-671,共3页
Journal of Clinical Pulmonary Medicine
关键词
无创机械通气机
法舒地尔
肺心病
呼吸衰竭
脑利钠肽
noninvasion mechanical ventilation
fasudil
cor pulmonale
respiratory failure
brain natfiuretic peptide
