摘要
非甲基化胞苷-磷酸盐-鸟苷(CpG)寡脱氧核苷酸(ODN)属于Toll样受体9(TLR9)激动剂,其功能主要通过TLR9信号系统来体现。根据构效关系,共鉴别出K型、D型、C型和P型4个类别的CpG ODN,分别对B细胞和浆细胞样树状突细胞产生不同刺激作用。无论单独应用CpG ODN,抑或联合化疗、放疗,还是联合靶向药物或疫苗,对非小细胞肺癌的治疗均有一定的增效作用。该文也简述了CpG ODN的安全性。
Unmethylated cytidine-phosphate-guanosine-containing oligodeoxynucleotides（CpG ODN） are Toll-like recep- tor 9（TLRg） agonists. TLR9 was identified as the mediator of the immunstimulatory effects of CpG ODN. Structure-activity relationship studies of CpG ODN has defined 4 categories： K,D,C and P types of CpG ODN with distinct structural and biologi- cal characteristics. They were potent activators of plasmacytoid dentritie cells （pDCs） and B cells,respectively. Over the last decade, experiments and clinical trials have been conducted to treat non-small-cell lung cancer with CpG ODN alone or com- bined with chemotherapy, radiotherapy, targeting agents and vaccines. Immunoenhancement was observed in these tests. The safety of CpG ODN was also described briefly.
出处
《药学服务与研究》
CAS
CSCD
2013年第1期30-33,共4页
Pharmaceutical Care and Research
基金
上海市浦东新区卫生系统学科带头人计划(PWRd2010-01)
上海市青年科技启明星计划(跟踪)(10QH1402000)
关键词
非甲基化胞苷-磷酸盐-鸟苷寡脱氧核苷酸
癌
非小细胞肺
Toll样受体9
肿瘤治疗方案
unmethylated cytidine-phosphate-guanosine-containing oligodeoxynucleotides （CpG ODN）
carcinoma, non- small-cell lung
Toll-like receptor 9
antineoplastic protocols
