摘要
目的:探讨珠海市社区65岁以上老年人代谢综合征流行病学及其与心电图P波间期离散度(Pwd)、QT间期离散度(QTd)的关系。方法:选择珠海市湾仔社区65岁以上的本地居民为研究对象,登记居民的健康资料、体格检查以及生化项目实验室检查数据。同时记录标准12导联心电图,测量P波间期、Pwd、QT间期(QT)、QTd,计算校正的QT间期(QTc)、校正的QT间期离散度(QTcd),计算胰岛素抵抗指数(HOMA-IR)。结果:完成筛查的65岁以上老年居民385例,代谢综合征的患病率为30.13%。排除75例可能对心电图有影响的情况后,共310例纳入本研究。其中69例诊断为代谢综合征,纳入代谢综合征组(MS组),余下241例纳入非代谢综合征组(NMS组)。MS组在性别、高血压患病率、腹型肥胖比例、体质指数、血糖、空腹胰岛素、血脂、尿酸、超敏C反应蛋白、胰岛素抵抗、收缩压方面与NMS组相比有显著差异,两组在年龄、舒张压方面比较差异无统计学意义(P>0.05)。在心电图方面,MS组的心率、Pwd、QTc、QTd、QTcd明显高于NMS组(P<0.05或<0.001),而两组QT间期的比较无统计学差异(P>0.05)。结论:患代谢综合征的老年居民可表现出心电图Pwd、QTc、QTd、QTcd明显延长,需重视对这部分人群心电图的检测及心律失常的预防。
Objective To investigate the prevalence of metabolic syndrome （MS） and its relationship with ECG P wave dispertion （Pwd）, QT dispersion （QTd） in elderly residents aged over 65 years in Zhuhai. Methods The residents aged over 65 years old in Wanzai community in Zhuhai were screened. The healthy information was collected, and the physical examination and laboratory tests were performed. Meanwhile, standard 12-lead ECG were performed for all residents and the P wave interval, Pwd, QT, and QTd intervals were evaluated; then QTc and QTcd were calculated. Also, the insulin resistance index （HOMA-IR） was estimated. Results Totally 385 elderly residents over 65 years old were screened. The prevalence of MS was 30.13%. 75 cases with factors affecting ECG were excluded, and then a total of 310 residents were enrolled in the study. 69 cases diagnosed as MS were included in MS group, and the remaining 241 cases were included in non-MS group （NMS group）. The differences of gender, proportion of hypertension and abdominal obesity, body mass index, blood glucose, fasting insulin, lipids, uric acid, and high-sensitivity C-reactive protein, insulin resistance, and systolic blood pressure were significant between the residents in MS group and NMS group （P 〈 0.05 or P 〈 0.001）; while those of age and diastolic blood pressure was not significant （P 〉 0.05）. In the aspect of ECG, the heart rate, Pwd, QTc, QTd, and QTcd in MS group were significantly higher than those in NMS group （P 〈 0.05 or P 〈 0.001）, while the difference of QT between the two groups was not significant （P 〉 0.05）. Conclusions Elderly residents suffering from MS could exhibit significantly longer Pwd, QTc, QTd and QTcd. We should pay more attention to detecting these kinds of people with ECG and to preventing the arrhythmia.
出处
《实用医学杂志》
CAS
北大核心
2013年第5期816-819,共4页
The Journal of Practical Medicine
基金
国际肾脏病学会研究与预防委员会资助项目(编号:ISN-COMGAN,2007)
欧盟第七框架计划资助项目(编号:Urosense286386)
广东省科技计划项目(编号:2011B031800386)
