摘要
Since its discovery over a decade ago, Disrupted in Schizophrenia 1 （DISCI） has been implicated in a wide spectrum of brain-specific phenotypes, ranging from severe mental disorders such as major depression, schizophrenia and bipolar disorder to more subtle alterations of brain structure and function, and including multiple defects of neurodevelopment and neuronal plasticity. Collectively, these observations have established DISCI as a widely recognised candidate gene for major psychiatric illness, and many studies have exploited it as a tool to dissect the cellular and molecular perturbations underlying these highly heritable disorders. DISCI encodes a large multifunctional protein that is expressed at relatively high levels in the brain, where it distributes to multiple subcellular compartments in both neurons and glia. DISCI can physically interact with a large number of other proteins, many of which have well-established functions in several aspects of neuronal development and neurosignalling, and some of which have been independently associated with psychiatric illness.
Since its discovery over a decade ago, Disrupted in Schizophrenia 1 （DISCI） has been implicated in a wide spectrum of brain-specific phenotypes, ranging from severe mental disorders such as major depression, schizophrenia and bipolar disorder to more subtle alterations of brain structure and function, and including multiple defects of neurodevelopment and neuronal plasticity. Collectively, these observations have established DISCI as a widely recognised candidate gene for major psychiatric illness, and many studies have exploited it as a tool to dissect the cellular and molecular perturbations underlying these highly heritable disorders. DISCI encodes a large multifunctional protein that is expressed at relatively high levels in the brain, where it distributes to multiple subcellular compartments in both neurons and glia. DISCI can physically interact with a large number of other proteins, many of which have well-established functions in several aspects of neuronal development and neurosignalling, and some of which have been independently associated with psychiatric illness.
