摘要
目的研究可溶性膳食纤维对2型糖尿病患者胃排空、血糖和血胰岛素水平的影响。方法选取30例2型糖尿病患者，采用随机Cross-over方法分别先后摄取不含膳食纤维溶液（500 ml，2092 kJ）和等热量含可溶性膳食纤维溶液（可溶性纤维7.5 g，500 ml，2092 kJ）试餐，采用B超法每间隔30分钟测定餐后胃排空，同时测定餐后血糖和血胰岛素。并以10名健康志愿者为对照组。结果可溶性膳食纤维试餐使糖尿病组（P=0.001）和对照组（P=0.037）近端胃半排空时间显著延迟。可溶性膳食纤维显著降低糖尿病患者餐后血糖（P=0.001）和血胰岛素（P=0.001）曲线下面积，且餐后血糖（r=-0.547, P=0.047）及血胰岛素（r=-0.444, P=0.030）水平与远端胃排空呈显著负相关。可溶性膳食纤维使13例糖化血红蛋白（HbA1c）≥6.5%的糖尿病患者（P=0.021）远端胃排空显著延迟。结论可溶性膳食纤维改善糖尿病患者餐后血糖，并可能与其延迟胃排空有关。可溶性膳食纤维使平均血糖水平较高的糖尿病患者胃排空显著延迟。
ObjectiveTo investigate the impacts of soluble dietary fiber （SDF） on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes mellitus （T2DM）. MethodsTotally 30 T2DM patients and 10 healthy subjects （control group） were randomized to receive SDF-free liquid （500 ml, 2092 kJ） and isocalorie SDF liquid （at β-glucan 7.5 g, 500 ml, 2092 kJ） on two separate days based on a Cross-over order. Gastric emptying was monitored by ultrasomography at intervals of 30 min for 2 hours. Fasting and postprandial blood samples were collected at intervals of 30-60 min for 180 min to determine blood glucose and insulin. ResultsThe proximal gastric emptying was delayed in SDF both in T2DM group （P=0.001） and control group （P=0.037）. SDF significantly decreased the area under the curve of postprandial glucose （P=0.001） and insulin （P=0.001） in T2DM group. Postprandial glucose （r=-0.547, P=0.047） and insulin （r=-0.444, P=0.030） had negative correlation with distal emptying of SDF in T2DM patients. The distal gastric emptying was delayed significantly in T2DM patients with HbA1c≥6.5% （n=13, P=0.021） by SDF. ConclusionsSDF can improve the postprandial glucose level, which may be related with the delayed gastric emptying. T2DM patients with higher average blood glucose has remarkably delayed gastric emptying after the administration of SDF.
出处
《中华临床营养杂志》
CAS
CSCD
2013年第1期3-7,共5页
Chinese Journal of Clinical Nutrition
基金
国家高科技研发项目（国家863课题）（2010AA023007）
关键词
可溶性膳食纤维
胃排空
血糖
血胰岛素
Soluble dietary fiber
Gastric emptying
Blood glucose
Plasma insulin
