期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

质粒介导的KPC-2型碳青霉烯酶水平传播机制的探讨 被引量：2

原文传递
导出
摘要 目的了解河南省人民医院耐美罗培南肺炎克雷伯菌和日勾维肠杆菌是否携带KPC型碳青霉烯酶基因,探讨blaKPC基因的水平传播机制。方法采用琼脂稀释法进行药物敏感性试验,PCR检测KPC编码基因,质粒电转化试验分析blaKPC基因能否水平传播,质粒酶切电泳图谱判断质粒的相似性。结果两株耐美罗培南肺炎克雷伯菌和日勾维肠杆菌均检测出KPC型碳青霉烯酶基因,测序比对结果显示为KPC-2型碳青霉烯酶,其编码基因blaKPC-2位于质粒上,并且可以在细菌之间进行水平传播。结论质粒介导的KPC-2型碳青霉烯酶是我院肠杆菌科细菌耐药性水平传播的机制之一。
作者 许俊红 王中全
机构地区 河南省人民医院检验科 郑州大学第一附属医院
出处 《医药论坛杂志》 2013年第1期87-88,共2页 Journal of Medical Forum
关键词 KPC-2型碳青霉烯酶 质粒 水平传播
分类号 R446.5 [医药卫生—诊断学]
  • 相关文献

参考文献8

  • 1Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem - hydrolyzing beta - lactamase, KPC - 1, from a carbapenem - resistant strain of K|ebsiella pneumonia [ J ]. Antimicrob Agents Chemother, 2001,45 : 1151. 被引量：1
  • 2Giani T, Tascini C, Arena F, et al. Rapid detection of intestinal carriage of KlebsieUa pneumoniae producing KPC carbapenemase during an outbreak[J]. J Hosp Infect,2012 Jun,81 (2):119- 22. 被引量：1
  • 3Cuzon G, Naas T, Demachy MC, et al. Plasmid - mediated car- bapenem - hydrolyzing beta - lactamase KPC - 2 in Klebsiella pneumoniae isolate from Greece [ J ]. Antimicrob Agents Che- mother, 2008,52:796. 被引量：1
  • 4DrorM, Shift NV, Leavitt A, et al. Isolation of Imipenem - Re- sistant Enterobacter Species : Emergence of KPC - 2 carbap - en- emase, M01 ecular Characterization, Epidemiology, and Outcomes[ J]. Antimicrob Agents Chemother, 2008, 52:2066- 2069. 被引量：1
  • 5张幸国,杜小幸,张嵘,魏泽庆,俞云松,陈亚岗,李兰娟.发现一株产KPC-2型碳青霉烯酶肺炎克雷伯菌[J].中华检验医学杂志,2006,29(9):824-826. 被引量：61
  • 6Alba J, Ishii Y, Thomson K, et al. Kinetics study of KPC -3, plasmid - encoded class A carbapenem - hydrolyzing [3 - lacta- mase[ J]. Antimicrob Agents Chemother,2005 ,49 :4760. 被引量：1
  • 7Robledo IE, Moland ES, Aquino EA, et al. First report of a KPC-4 and CTX- M producing K. pneumoniae (KP) isolated from Puerto Rico. 47th Inter Science Conference on Antimicrobial Agents and Chemotherapy; Chicago, IL, USA; Sept 17 - 20, 2007. C2-1993. 被引量：1
  • 8Naas T, Cuzon G, Villegas MV et al. Genetic structures at the origin of acquisition of the beta - lactamase blaKPC gene [ J ]. Antimicrobial agents and chemotherapy,2008,52:1257. 被引量：1

二级参考文献11

  • 1Moland ES, Black JA, Ourada J, et al. Thomson KS. Occurrence of newer beta-lactamases in Klebsiella pneumoniae isolates from 24 U.S. hospitals. Antimicrob Agents Chemother, 2002, 46:3837-3842. 被引量：1
  • 2Bratu S, Landman D, Haag R, et al. Rapid spread of carbapenemresistant KlebsieUa pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med, 2005, 165:1430-1435. 被引量：1
  • 3We ZQ, Chen YG, Yu YS et al. Nosocomial spread of multiresistant Klebsiella pneumoniae containing a plasmid encoding multiple β-lactamases. J Med Microb, 54:885-888. 被引量：1
  • 4Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing beta-laetamase, KPC-1, from a earbapenem-resistant strain of Klebsiella pneumoniae. Antimierob Agents Chemother,2001,45:1151-1161. 被引量：1
  • 5Walsh TR, Toleman MA, Poirel L, et al. Metallo-beta-lactamases:the quiet before the storm? Clin Microbiol Rev, 2005, 18:306-325. 被引量：1
  • 6Brown S, Amyes S. OXA {beta}-lactamases in Acinetobacter:the story so far. J Antimicrob Chemother, 2006, 57:1-3. 被引量：1
  • 7Yah JJ, Ko WC, Wu JJ. Identification of a Plasmid Encoding SHV-12, TEM-1, and a Variant of IMP-2 Metallo-β-Lactamase, IMP-8,trom a Clinical Isolate of Klebsiella pneumoniae. Antimicrob Agents Chemother, 2001,45:2368-2371. 被引量：1
  • 8Poirel L, Heritier C, Tolun V, et al. Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.Antimicrob Agents Chemother, 2004, 48:15-22. 被引量：1
  • 9Bradford PA, Urban C, Mariano N, et al. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1,a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein. Antimlcrob Agents Chemother, 1997, 41:563-569. 被引量：1
  • 10Hossain A, Ferraro MJ, Pino RM, et al. Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp.Antimicrob Agents Chemother, 2004, 48:4438-4440. 被引量：1

共引文献60

同被引文献14

  • 1CHEN YT, LIN JC, FUNG CP, et al.KPC- 2-encoding plasmids from Escherichia coli and KlebsieIla pneumoniae in Taiwan[J]. J Antimicrob Chemother, 2014, 69 (3) : 628-631. 被引量：1
  • 2NORDMANN P, NAAS T, POIREL L. Global spread of carbapenemase-producing Enterobacteriaceae[J]. Emerg Infect Dis, 2011, 17 (10) : 1791-1798. 被引量：1
  • 3CHMELNITSKY I, SHKLYAR M, HERMESH O, et al. Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258[J]. J Antimicrob Chemother, 2013, 68 (1) : 74-83. 被引量：1
  • 4Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; twenty-third informational supplement[S]. M100-$23, CLSI, 2013. 被引量：1
  • 5PIC.O RC, ANDRADE SS, NICOLETTI AG,et al. Metallo-beta-lactamase detection: comparative evaluation of double-disk synergy versus combined disk tests for IMP-, GIM-, SIM-, SPM-, or VIM- producing isolates[J]. J Clin Microbiol, 2008, 46 (6) : 2028-2037. 被引量：1
  • 6DALLENNE C, DA COSTA A, DECRI D, et al. Development of a set of multiplex PCR assays for thedetection of genes encoding important beta- lactamases in Enterobacteriaceae[J]. J Antimicrob Chemother, 2010 , 65 (3) : 490-495. 被引量：1
  • 7RAHMAN M, SHUKLA SK, PRASAD KN, et al.Prevalence and molecular characterisation of New Delhi metallo--lactamases NDM-I, NDM-5, NDM-6 and NDM-7 in multidrug-resistant Enterobacteriaceae from India[J]. Int J Antimicrob Agents, 2014, 44 (1) : 30-37. 被引量：1
  • 8QUEENAN AM, BUSH K. Carbapenemases: the versatile beta-lactamases[J].Clin Microbiol Rev, 2007, 20 (3) : 440-458. 被引量：1
  • 9MENA A, PLASENCIA V, GARCIA L, et al. Characterization of a large outbreak by CTX-M- 1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development[J]. J Clin Microbiol, 2006, 44 ( 8 ) : 2831-2837. 被引量：1
  • 10YANO H, KUGA A, OKAMOTO R, et al. Plasmid-encoded metallo-beta-lactamase ( IMP-6 ) conferring resistance to carbapenems, especially meropenem[J].Antimicrob Agents Chemother, 2001, 45 (5) : 1343-1348. 被引量：1

引证文献2

二级引证文献32

医药论坛杂志
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部