摘要
目的:探讨太阳病(风寒表证)白介素-1(IL-1)变化规律。方法:以文献报道"小鼠风寒表证"疾病模型制作方法为基础,结合预实验的经验制作动物模型,与正常组比较一周内白介素-1(IL-1)的变化。结果:正常组、实验组白介素-1(IL-1)表现为昼低夜高的变化;在风寒表证7天疾病周期中,实验组IL-1的表达高于正常组(P<0.01);实验组小鼠体内IL-1的表达逐渐上升,于发病第3天达到高峰,以后逐渐下降;实验组IL-1的变化曲线与正常组基本平行。结论:IL-1存在昼夜变化节律;IL-1的高表达出现在太阳病第2～3天,此后逐渐回落,基本吻合外感表证7天自愈的病程;实验组白介素-1(IL-1)水平昼低夜高的变化,与三阴病欲解于夜间,三阳病欲解于昼时的认识一致。
Objective ： To study the variation of interleukin （ IL - 1 ） in Taiyang disease （ wind cold superficies syndrome）. Meth- ods：Based on the mice wind cold superficies syndrome model reported in literature,we could build the animal modet according to the pre-experiment, from which we could compare with the normal group to observe the variation of IL - 1 in a week. Results ： IL - 1 in the normal group and the experimental group had a change of low in day and high at night. Within the disease cycle of wind cold superficies syndrome which lasted seven days, the expression of IL - 1 in experimental group was higher than that in normal group（ P 〈 O. O1 ）. The expression of IL - 1 in mice of experimental group was increasing, which could reach a peak on the third day of pathogenesis, and was decreasing afterwards. The variation curve of expression of IL - 1 in mice of experimental group was basically parallel to that of the normal group. Conclusion：There was diurnal variation in IL - 1. The high expression of IL - 1 is appeared on the second day and the third day of Taiyang disease, and then the expression is gradually decreasing. This phenome- non is coincided with the self-healing of exogenous superficies syndrome in seven days. The variation of IL - 1 in experimental group which is low in day and high at night,is agreed with Sanyin disease tending to be cured at night and Sanyang disease tend- ing to be cured in day.
出处
《辽宁中医杂志》
CAS
2013年第3期396-398,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金地区科学基金项目(30960471)
关键词
太阳病
欲解时
白介素-1
相关性
Taiyang disease
disease tending to be cured
Interleukin 1（ IL- 1）
correlation
