摘要
目的评价国产6%羟乙基淀粉130/0.4对食管癌根治术老年患者围术期肾功能的影响。方法选择2009年2—11月拟择期全麻行食管癌根治术的患者40例为研究对象,采用随机数字表法分为两组,A组术中给予进口6%羟乙基淀粉130/0.4氯化钠注射液(万汶)20 ml/kg;B组术中给予国产6%羟乙基淀粉130/0.4氯化钠注射液(天晴宁)20 ml/kg。记录和检测进入手术室后输液前(T0)、术毕(T1)、术后第1天(T2)及术后第2天(T3)心率、收缩压、舒张压、中心静脉压(CVP)、脉搏血氧饱和度(SpO2)及血清肌酐(Cr)、尿素氮(BUN)、肾小球滤过率(GFR)和β2-微球蛋白(β2-M)水平。结果 A组与B组不同时间点心率、收缩压、舒张压、SpO2比较,差异均无统计学意义(P>0.05);两组不同时间点CVP比较,差异有统计学意义(F时间=0.712,P=0.698,F组间=37.854,P=0.000);其中A组和B组T1、T2、T3时间点CVP均高于T0,差异有统计学意义(P<0.05)。两组不同时间点Cr、BUN水平比较,差异均有统计学意义(F时间=0.961,P=0.493,F组间=20.272,P=0.000;F时间=0.760,P=0.543,F组间=24.648,P=0.000);其中A组和B组T1时间点Cr、BUN均高于T0,差异有统计学意义(P<0.05)。两组不同时间点GFR、β2-M水平比较,差异均无统计学意义(P>0.05)。结论国产6%羟乙基淀粉130/0.4注射液对老年患者肾功能无明显影响,血流动力学稳定,值得临床推广应用。
Objective To evaluate the influence of Tianqingning on the renal function of aged patients in perioperative period. Methods 40 patients with esophageal cancer to be given radical operation from February to November in 2009 were ran- domly divided into group A and group B. Group A was given 20 ml/kg sodium chloride injection of Voluven, while group B was given 20 mL/kg sodium chloride injection of Tianqingning. Heart rate （HR）, SBP, DBP, CVP, SpO2, serum creatinine （ Or）, blood urea nitrogen （ BUN）, glomerular filtration rate （GFR） and β2 - microglobulin （ β2 - M） were tested and recor- ded before transfusion （ TO ）, after operation （ T1 ）, one day after operation （ T2 ） and two days after operation （ T3 ） . Results HR, SBP, DBP and SpO2 at different times between group A and group B showed no statistically significant differences （ P 〉 0. 05 ） . The CVP at different times between the two groups showed statistically significant differences （Fintra-group= 0. 712, P = 0. 698 ; Finter-group = 37. 854, P = 0. 000）, and the CVP at TO was significantly higher than those in T1 , T2 and T3 both in group A and group B （ P 〈 0. 05 ） . The Cr and BUN at different times between the two groups showed statistically significant differences （Finter-group=0.961, P=0.493; Finter-group =20.272, P=0.000;Finter-group =0.760, P=0.543;Finter-group=24.648, P= 0. 000） . The Cr and BUN at T1 were both significantly higher than TO both in group A and group B （ P 〈 0.05 ） . The GFR and β2 - M at different times between the two groups showed no statistically significant differences （ P 〉 0. 05 ） . Conclusion Tian- qingning, namely the 6% hydroxyethyl starch 130/0. 4 injection, has no bad influence on the renal function of aged patients and has hemodynamic stability, so it should be recommended in clinic.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第6期682-685,共4页
Chinese General Practice
