摘要
目的观察CD13在胃癌组织中的表达情况及其与患者预后的关系。方法采用免疫组化S—P法检测104例胃癌组织和16例正常胃黏膜组织中CD13的表达。结果104例胃癌组织和16例正常胃黏膜中CD13表达阳性率分别为74％（77／104）和0，CD13在胃癌组织中的表达均高于正常胃黏膜组织，差异有统计学意义（P〈0．01）。CD13表达与胃癌患者年龄、性别、淋巴转移无相关性（P〉0．05），而与肿瘤大小、临床分期、分化程度及患者5年生存率差异有统计学意义（P〈0．05）。结论CD13在胃癌中的异常表达与胃癌的发生、发展有关，可作为评估胃癌的恶性程度、指导治疗、评价预后的重要参考指标。
Objective To investigate the expressions of the CD13 in gastric cancer and the relationships be- tween it and the patients＇ prognosis. Methods The expressions of CD13 were detected by immunohistochemical （SP method） in 10,＊ cases of gastric cancer and 16 cases of normal gastric mucosa. Results The expressions of CD13 in 104 cases of gastric carcinoma and 16 cases of normal gastric mucosa show positive rate were 74% （77/104） and 0% , respectively. The expressions of CD13 in gastric cancer were higher than in normal gastric mu- cosa and the difference was statistically significant （ P 〈 0.01 ）. The expressions of CD13 in gastric cancer were not relative to patients＇ age, gender, and lymph node metastasis （P 〉 0.05）, but to be correlative with tumor sizes, clinical stage, degree of differentiation, and patients＇ 5- year survival rate （ P 〈 0.05 ）. Conclusions The abnor- mal expression of CD13 in the gastric cancer may be correlative with the occurrence and development of gastric cancer, which can be an important indicator to evaluate the degree of malignance, guide treatment and assess uncer- tain prognosis of gastric cancer.
出处
《国际外科学杂志》
2013年第2期101-104,F0004,共5页
International Journal of Surgery
关键词
胃肿瘤
抗原
CD13
免疫组织化学
Stomach neoplasms
Antigens, CDI3
Immunohistoehemistry
