摘要
目的探讨良、恶性胃溃疡组织中PTEN和survivin的表达变化及临床意义。方法采用免疫组化SP法检测63例无癌前病变的胃溃疡、68例有癌前病变胃溃疡及83例溃疡型胃癌组织中PTEN和survivin蛋白的表达,分析二者的相关性及其与溃疡型胃癌病理特征的关系和临床价值。结果无癌前病变、有癌前病变的胃溃疡及溃疡型胃癌组织中PTEN表达逐渐下降(P<0.01),survivin表达逐渐升高(P<0.01),二者的表达呈负相关(r=-0.489,P<0.01)。PTEN表达与溃疡型胃癌分化类型有关(P<0.01),survivin表达与有癌前病变胃溃疡病理进展有关(P<0.05)。PTEN、survivin在溃疡型胃癌检测中特异度分别为79.39%、57.25%,灵敏度分别为52.38%、71.08%。结论良、恶性胃溃疡组织中PTEN和survivin蛋白表达不同,检测其组织中PTEN和survivin对良、恶性胃溃疡的鉴别及观察溃疡的组织演变可能具有重要意义。
Purpose To discuss the expression of PTEN and survivin protein and their significance in benign and malignant gastric ul- cer. Methods By using SP immunohistochemieal staining from different gastric ulcer mucosa, we detected the expression of PTEN and survivin, including 63 cases of non-precancerous lesion, 68 precancerous lesions and 83 gastric ulcers. The correlation was ana- lyzed between both and pathological characteristics of ulcerated gastric cancer with their clinical values. Results From gastric ulcer mucosa, non-precancerous lesion and precancerous lesion to gastric cancer, the expression of PTEN tended to decrease （P 〈 0. 01 ）, and survivin expression tended to increase （P 〈 0. 01 ）. The expression of PTEN was negatively correlated with the expression of sur- vivin （r = -0. 489, P 〈 0. 01 ）. The expression of PTEN was related with differentiation degree （P 〈 0. 01 ） , and survivin expression related with pathological progression （ P 〈 0. 05 ）. For the detection of ulcerated gastric carcinoma, the specificity of PTEN and survivin was 79. 39% and 57.25%, and the sensitivity was 52. 38% and 71.08%, respectively. Conclusion The expression of PTEN and survivin protein in benign and malignant gastric ulcer is different. The detection of PTEN and survivin may play a role in clinical identi- fication of both benign and malignant gastric ulcers and the progression of gastric ulcer.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2013年第2期167-170,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
合肥市科技局重点立项资助[合科(2011)25号]
