摘要
目的 研究霉酚酸酯 (MMF)对大鼠角膜移植排斥反应的防治作用。方法 建立大鼠穿透性角膜移植排斥反应的动物模型 ,观察MMF对大鼠角膜移植片存活的影响 ,并与阴性对照组和CsA治疗组相比较。结果 阴性对照组角膜植片平均存活时间为 11 375± 1 6 85天 ,CsA治疗组为 18 6 2 5± 1 5 98天 ,MMF治疗组为 16 5 0 0± 1 85 2天 ,CsA +MMF组为 2 4 5 0 0±1 773天 ,均比阴性对照组显著延长。结论 MMF对大鼠穿透性角膜移植排斥反应具有抑制作用 ,显著地延长角膜植片的存活时间。
To study the efficacy of immunosuppressant mycophenolate mofetil in the rat model of penetrating keratoplasty.Methods Corneal grafts were transplanted orthotopically from Lou rats to F344 rats recipients.Animals were randomly assigned to the following groups:1.control;2.CsA(10 mg/kg/d p.o.);3.MMF(40 mg/kg/d p.o.);4.CsA+MMF(CsA 10 mg/kg/d and MMF 40 mg/kg/d p.o.).Treatment was began on the first postoperative day and continued until the 14th days.Mean survival times were determined. Results The mean survival time of the untreated group was merely 11.375±1.685 days,But the mean survival time of the treated groups with CsA and MMF were respectively 18.625±1.598 days and 16.500±1.852 days,and The mean survival time of the combined therapy group was 24.500±1.773 days,which was statistically,significant compared with all other groups. Conclusion MMF can markedly prolongs the survival time of corneal allografts by inhibiting graft rejection as CsA do.
出处
《眼外伤职业眼病杂志》
北大核心
2000年第6期630-631,共2页
Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries
