摘要
氯丙醇类化合物3-氯-1,2-丙二醇(3-MCPD)是目前国际上广为关注的食品污染物,最初发现在酸水解植物蛋白加工而成的食品中。近年来,许多食品特别是精制油中发现大量3-MCPD脂类,其能够在体内通过代谢途径产生3-MCPD。研究发现3-MCPD在啮齿类动物中存在明显的毒性作用,且具有种属和位点特异性。结合国内外毒理学研究成果,概述3-MCPD体内代谢途径,详细综述其急性毒理、致癌性以及遗传、生殖、免疫、神经毒性机制的研究进展,并展望了3-MCPD毒理学评价进一步研究的方向。
3-Monochloropropane-1 ,2- diol （3- MCPD） is a well- known contaminant that has been detected in a wide range of foods, originally identified in foods prepared by hydrochloric acid hydrolysis.More recently ,fatty acid esters of 3-MCPD,which could release free of 3-MCPD by hydrolysis, have been found in various types of foods, most notably high levels were measured in refined vegetable oils.Studies have been found that 3-MCPD have clear toxic effect with species and site specific in rodents. In this paper, the domestic and foreign toxicological researches were reviewed, which related to metabolic pathways of 3- MCPD. The toxicity of 3- MCPD were discussed in detail from the aspect of shortterm toxicity, carcinogenicity, genotoxicity, reproductive toxicity, immunotoxicity, neurotoxicity.On these bases,further toxicological research directions were pointed out.
出处
《食品工业科技》
CAS
CSCD
北大核心
2013年第5期358-362,共5页
Science and Technology of Food Industry
基金
"十二五"863计划课题(2013AA102202)
国家自然科学基金(31201340)
"十二五"国家科技支撑计划课题(2012BAK01B03)
关键词
3-氯-1
2-丙二醇
毒理
食品安全
进展
3- Monochloropropane- 1,2- d iol
toxicology
food safety
progress
