摘要
四溴双酚A(tetrabromo-bisphenol A,TBBPA)是一种全球范围广泛应用的溴代阻燃剂(bromination flameretardant,BRF),在各种环境介质及动物、人体内已均被检出。TBBPA对水生生物的毒性效应及其机制的研究对开展TBBPA危害的早期预警及生态暴露风险评价具有重要意义。该文综述了TBBPA对鱼类的急性毒性、肝脏毒性、甲状腺干扰效应、神经毒性、生殖毒性及毒性机制。近年来,随着分子生物学技术的不断进步,国内外关于TBBPA对鱼类的毒性效应及其分子机制的研究也从个体、器官水平向蛋白、基因水平发展,这将成为今后的主要研究方向。
Tetrabromo-bisphenol A （TBBPA） was one kind of bromination flame retardants （BRFs）which was widely used worldwide. It had been detected out in various kinds of environmental media, as well as bodies of animals and humans. Researches on the strong toxicity to aquatic organisms of TBBPA were significant for its early warning and ecological exposure risk assessment. This review synthesized the acute toxicity, toxicity on the liver, the thyroid interference effects, neurotoxicity, reproductive toxicity and the mechanisms of TBBPA on fishes by referring to the published domestic and overseas articles. With the rapid developments on molecular biological technologies in recent years,studies on TBBPA toxic effects and the mechanisms on fishes had been promoted from individual and organ level to protein and genetic level,which provided new opportunities especially for researches on toxic mechanisms of environmental pollutants and the biological markers exploration.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2013年第2期178-181,共4页
Journal of Environment and Health
基金
环境保护部国家环保公益性行业科研专项(GYH5011001)
关键词
四溴双酚A
鱼类
毒性效应
分子机制
Tetrabromo-bisphenol A
Fish
Toxicity effect
Molecular mechanism
