摘要
目的观察心理干预联合帕罗西汀治疗原发性高血压伴抑郁症患者的临床效果。方法将伴有抑郁症的高血压患者60例随机分为治疗组和对照组各30例,对照组仅接受降压治疗,治疗组在对照组治疗基础上接受心理干预及抗抑郁治疗,比较2组患者治疗3个月后血压、汉密尔顿抑郁量表(HAMD)及生活质量评分。结果治疗后2组患者收缩压、舒张压、HAMD评分均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05和P<0.01)。治疗组患者治疗后躯体功能、心理功能、社会功能、物质功能及生活质量总分均高于治疗前,差异有统计学意义(P<0.05);而对照组治疗前后比较差异无统计学意义(P>0.05)。结论对原发性高血压伴抑郁患者在常规降压治疗基础上进行心理干预和抗抑郁治疗,对血压的控制较单纯降压药物治疗效果更好,且有利于提高患者生活质量。
Objective To observe the clinical effect of psychological intervention combined with paroxetine in the treatment of essential hypertensive complicated with depression. Methods 60 patients with depression and hypertension were randomly divided into treatment group and control group, each of 30 cases. The control group only received antihypertensive therapy, the treatment group accepted psychological intervention and antidepressant for treatment based on the control group. 3 months after treatment, the blood pressure, Hamilton depression scale （HAMD） and life quality score of 2 groups were compared. Results After 3 months of treatment,the systolic and diastolic blood pressure and HAMD of 2 groups were significantly decreased , and the treatment group was lower than the control group, and the differences were statistically significant （P 〈 0.05 ,P 〈 0.01 ）. After treatment, the score of body function, mental function, social function, physical function and quality of life increased significantly compared with before treatment in the treatment group, the differences were statistically significant （ P 〈 0. 05 ）. There was no significant difference before and after treatment in the control group （P 〉 0.05 ）. Conclusion It is effectively for using psychological intervention and antidepressant treatment in the treatment of essential hypertensive complicated with depression bases on the conventional treatment, which is better than antihypertensive therapy only on blood pressure control and can improve the quality of life of patients.
出处
《临床合理用药杂志》
2013年第5期10-11,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
原发性高血压
抑郁
心理干预
帕罗西汀
Essential hypertension
Depression
Psychological intervention
Paroxetine
