摘要
目的观察舒肝解郁胶囊联合舍曲林治疗脑卒中后抑郁障碍(PSD)的临床疗效。方法将89例脑卒中后抑郁障碍患者随机分为两组,研究组45例,给予舒肝解郁胶囊与舍曲林治疗,对照组44例,给予舍曲林治疗,6周为一疗程。于治疗前及治疗后1、2、4、6周末采用HAMD、TESS、CGI-SI分别进行评定。结果与治疗前比较:研究组在治疗后各时点的HAMD评分及CGI-SI评分均有改善(P<0.05);与对照组比较:研究组在治疗后各时点的HAMD评分及CGI-SI评分的改善均优于对照组(P<0.05)。6周末疗效比较,研究组较对照组差异有统计学意义(χ2=4.68,P<0.05)。两组治疗期间TESS评分各时点差异均无统计学意义(P>0.05)。结论舒肝解郁胶囊联合舍曲林治疗脑卒中后抑郁障碍疗效优于单用舍曲林,且起效较快。
Objective To observe the clinical effect of Shuganjieyu Capsules combining with Sertraline treat Post-stroke Depression.Methods Divided 89 cases of Post-stroke Depression patient into 2 groups randomly.We cured 45 patients in the Investigate Group using both Shuganjieyu Capsules and Sertraline,and 44 patients in the Control Group using Sertraline alone for a period of treatment which included 6 weeks.Before treatment and after,the last day of first week,second,fourth and sixth,we assessed it respectively with HAMD,TESS and CGI-SI.Results Compared with before treatment：after treatment,the scores of HAMA and CGI-SI were improved at each time point in Investigate Group（P0.05）.Compared with the Control Group： the scores of HAMA and CGI-SI at each time point in Investigate Group was better than it in Control Group after treatment（P0.05）.Comparison on efficacy in the sixth weekend,there was signigicant difference between Investigate Group and Control Group（χ2=4.68 P0.05）.During treatment,both groups＇ scores at each time point had no significant difference（（P0.05））.Conclusion The Curative effect of Shuganjieyu Capsules combined with Sertraline was better than it of Sertraline alone on the treatment of Post-stroke Depression and worked faster on efficacy.
出处
《中国实用医药》
2013年第4期18-19,共2页
China Practical Medicine
关键词
卒中后抑郁障碍
舒肝解郁胶囊
舍曲林
治疗
Post-stroke Depression
Shuganjieyu capsules
Sertraline
treatment
