摘要
目的调查我院2011年临床分离病原菌对抗菌药物的耐药性。方法用纸片扩散法进行抗菌药物敏感实验,参照CLSI 2011标准,用WHONET 5.5软件进行数据分析。结果临床分离的2535株病原菌中,革兰阳性菌占27.5%,革兰阴性菌占72.5%。耐甲氧西林金黄色葡萄球菌和凝固酶阴性葡萄球菌株检出率分别为43.5%和77.6%;发现2株耐利奈唑胺的粪肠球菌,未发现对万古霉素或替考拉宁耐药的葡萄球菌、屎肠球菌和粪肠球菌。肠杆菌对碳青霉烯类仍然敏感率高,总耐药率<1%。鲍曼不动杆菌对碳青霉烯类耐药率在65%以上,未发现泛耐药菌株。结论细菌的耐药对临床构成严重威胁,需规范临床合理使用抗菌药物。
Objective To investigate the antimicrobial resistance of clin- ical isolates from the first affiliated hospital of Chongqing Medical University in 2011. Methods Disk diffusion method was used to determine the antimicrobial susceptibility. And the WHONET 5.5 software was used to analyze the data according to the data of CLSI 2011. Results A total of 2535 clinical isolates, gram - positive organisms accounted for 27.5% , and gramnegative organisms 72.5%. The detection rates of methicillin -resistant Staphylococcus aureus （MRSA）and coagulase -negative Staphylococci （CNS） were 43.5% and77.6% , respectively. Two strains of E.faecalis were found resistant to linezolid. Staphylococci and Enterococcus were not found resistant to vancomycin or teicoplanin. The strains of Enterobacteriaceae were still highly susceptible to carbapenems. Overall less than 1% of these strains were resistant to carbapenems. The rate of carbapenem resistant in Acinetobacter spp. was more than 65%. No Pan. drug resistant strains were found. Conclusion It poses a serious threat to clinical practice and implies the importance of rational usage of clinical antimicrobials.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2013年第2期142-144,共3页
The Chinese Journal of Clinical Pharmacology
关键词
细菌
耐药
药物敏感性
bacteria
resistance
antimicrobial susceptibility
