摘要
目的通过对维持性血液透析(MHD)患者甲状旁腺素(PTH)与超敏C-反应蛋白(hs-CRP)、血清碱性磷酸酶(ALP),血清总钙(Ca)、血清磷(P)及血红蛋白(Hb)的水平进行检测,探讨PTH与hs-CRP对MHD患者的微炎症状态及肾性骨病和肾性贫血的影响。方法采用电化学发光法,散射比浊法,酶法,偶氮砷法,直接紫外分光法,SLS法分别对本院肾病科血液透析中心MHD患者91例的PTH与hsCRP、ALP,Ca、P及Hb进行检测,与健康对照组比较,并进行统计学分析。结果 91例MHD患者与60例健康对照组比较,MHD患者的PTH,hs-CRP,ALP,P,HB差异有统计学意义(P<0.01);PTH>300pg/mL组51例与PTH<300pg/mL组40例比较,PTH>300pg/mL组的hs-CRP和ALP均高于PTH<300pg/mL组,差异有统计学意义(P<0.05);而Ca、Hb和P差异无统计学意义(P>0.05)。结论 MHD患者PTH与hs-CRP升高严重影响着骨代谢并加重微炎症状态,也是导致红细胞生成素抵抗所致肾性贫血加重的原因之一。
Objective To detect the level of parathyroid hormone（PTH）,serum hypersensitive C-reactive protein（hs-CRP）,serum alkaline phosphatase（ALP）,serum total calcium（Ca）,serum phosphorous（P） and hemoglobin（Hb） in maintenance hemodialysis（MHD） patients,and then to explore the effect of the PTH and hs-CRP towards anemia or renal osteodystroph,as well as the micro-inflammatory status in MHD.Methods The PTH,hs-CRP,ALP,Ca,P and Hb levels were examined respectively by applying electrochemistry luminescence,scatter nephelometry,enzyme,arsenazo colorimetric method,direct ultraviolet and SLS method in 91 cases of maintenance hemodialysis patients of blood purification center in our hospital.The result was compared with the normal group and statistically analyzed.Results Comparing 91 MHD patients with 60 healthy people in normal group,there were statistical difference in PTH,hs-CRP,ALP,P and HB of the MHD patients（P〈0.01）.Comparing 51 cases in PTH 300 pg/mL group with 40 cases in PTH 300 pg/mL group,the levels of hs-CRP and ALP of the PTH 300 pg/mL group were higher than those of the PTH 300 pg/mL group,and there was statistical difference（P〈0.05）.While there was no statistical difference between Ca and P（P〈0.05）.Conclusion The higher levels of PTH and hs-CRP have severe effect on bone metabolization and the exacerbation of micro-inflammatory status in MHD patients,and that is also one of the reasons for the exacerbation of renal anemia caused erythropoietin resistance.
出处
《检验医学与临床》
CAS
2013年第4期409-410,412,共3页
Laboratory Medicine and Clinic
关键词
维持性血液透析
甲状旁腺素
超敏C-反应蛋白
maintenance hemodialysis
parathyroid hormone
hypersensitive C-reactive protein
