摘要
比较不同透析频率及方式治疗慢性肾功能衰竭尿毒症患者的临床疗效,为临床实践提供可靠的参考依据.方法选取2016年2月至2017年2月台州市中心医院肾内科收治的慢性肾功能衰竭尿毒症患者140例作为研究对象,利用完全随机分配法分为观察组和对照组各70例.对照组患者采用每周3次普通血液透析治疗,观察组患者采用每周3次普通血液透析联合1次血液透析滤过治疗,比较两组患者的临床治疗效果和并发症发生情况.结果与对照组血尿酸( BUA)[(532.09 ±71.05) mmol/L]、血肌酐(Scr)[(734.34 ±63.08)μmol/L]、血尿素氮(BUN)[(23.84 ±2.58) mmol/L]、血磷[(1.98 ±0.37)mmol/L]、甲状旁腺激素(PTH)[(464.37 ±113.92)ng/L]、β2 微球蛋白(β2-MG)[(13.48 ±6.38)mg/L]水平比较,观察组BUA[(495.89 ±58.23) mmol/L]、Scr [(684.34 ±77.32)μmol/L]、 BUN[(20.62 ±1.77) mmol/L]、血磷[(1.74 ±0.44)mmol/L]、PTH[(352.14 ±123.25)ng/L]、β2-MG[(9.58 ±5.45)mg/L]水平明显降低,两组差异均有统计学意义(t =3.29、4.19、8.61、3.49、5.59、3.88,均 P <0.01).与对照组皮肤瘙痒发生率(61.43%)比较,观察组皮肤瘙痒发生率(34.29%)低(χ^2 =9.72,P<0.01),两组其余并发症发生率差异均无统计学意义(χ^2 =1.14、1.58、3.08,均P>0.05).结论每周3次普通血液透析联合1次血液透析滤过治疗慢性肾功能衰竭尿毒症患者优势显著,可有效清除尿毒素分子,降低并发症发生率,值得临床推广应用.
Objective To observe the clinical efficacy of different dialysis frequency and methods in the treatment of chronic renal failure uremia patients ,and to provide a reliable reference for clinical practice.Methods From February 2016 to February 2017,140 chronic renal failure uremic patients who admitted to the Department of Nephrology at Taizhou Central Hospital were selected and divided into the observation group and the control group by complete random distribution method ,with 70 cases in each group.The patients in the control group received 3 times of regular hemodialysis treatment per week , while the observation group received 3 times of regular hemodialysis combined with 1 time of hemodiafiltration treatment per week.The clinical treatment effects and complications of the two groups were compared.Results Compared with blood uric acid ( BUA)[(532.09 ±71.05) mmol/L],serum creatinine(Scr)[(734.34 ±63.08)μmol/L],blood urea ( BUN)[(23.84 ±2.58) mmol/L],serum phosphorus [(1.98 ±0.37)mmol/L],parathyroid hormone ( PTH)[(464.37 ±113.92) ng/L],β2 microglobulin (β2 -MG)[(13.48 ±6.38)mg/L]in the control group,BUA[(495.89 ±58.23) mmol/L],Scr[(684.34 ±77.32)μmol/L], BUN[(20.62 ±1.77) mmol/L],serum phosphorus [(1.74 ±0.44) mmol/L],PTH[(352.14 ±123.25) ng/L],β2 -MG[(9.58 ±5.45) mg/L] were significantly lower in the observation group ,the differences were statistically significant (t=3.29,4.19,8.61,3.49,5.59,3.88,all P<0.01).Compared with the incidence rate of pruritus in the control group(61.43%),the incidence rate of pruritus in the observation group (34.29%) was significantly lower (χ^2 =9.72,P<0.01),the incidence of other complications had no statistically significant differences (χ^2 =1.14, 1.58,3.08,all P>0.05).Conclusion Hemodialysis 3 times combined with 1 time of hemodiafiltration per week has significant advantage in the treatment of chronic renal failure uremia patients ,which can effectively remove urine toxin molecules and reduce the incidence of complications ,and it is worthy of clinical app
作者
聂艳芳
万晓晴
陈媛
单艳梅
余海峰
李春胜
张薇
陈孜伟
Nie Yanfang;Wan Xiaoqing;Chen Yuan;Shan Yanmei;Yu Haifeng;Li Chunsheng;Zhang Wei;Chen Ziwei(Department of Nephrology,Taizhou Central Hospital ( Affiliated Hospital of Taizhou University ),Taizhou,Zhejiang 318000,China)
出处
《中国基层医药》
CAS
2019年第18期2252-2256,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肾功能衰竭
慢性
尿毒症
血液透析
血液透析滤过
疗效比较研究
Renal failure
chronic
Uremia
Hemodialysis
Hemodiafiltration
Comparative effec-tiveness research
