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精吡氟禾草灵原药的毒性研究

Study on the Mutagenicity and Subchronic Toxicity of Fluazifop-P-butyl TC
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摘要 目的探讨精吡氟禾草灵原药致突变性及亚慢性毒性。方法按照GB15670-1995《农药登记毒理学试验方法》进行。结果精吡氟禾草灵原药致突变性的试验结果与对照组比较差异无统计学意义(P>0.05)。亚慢性毒性试验中:中、高剂量组雌鼠碱性磷酸酶(AKP)增高;雄鼠体重较对照组有明显减轻,肝脏和脑的脏器系数增高;高剂量组雄鼠肾脏脏器系数增高。结论本试验提示精吡氟禾草灵原药无明显致突变作用,对动物脑、肝、肾等脏器有损伤作用。SD大鼠亚慢性(90 d)经口毒性的最大无作用剂量雌、雄分别为6.8和8.4 mg/kg.d。 Objective To study the mutagenicity and subchronic toxicity of fluazifop- P - butyl TC in rats. Methods The test was conducted in compliance with the National Standard of PRC, Toxicological Test Methods of Pesticides Jbr Regis- tration (GBl5670 - 1995). Results Fluazifop - P - butyl TC was negative for mutagenicity in Ames test, mice bone marrow cell micronucleus test and mice testicle cell chromosome aberration test. Subchronic toxicity test indicated that compared with the control group, the alkaline phosphatase(ALP)levels in the female rats in the middle and high dose groups were significantly elevated (P〈 0.05). The body weights were statistically decreased (P 〈 0.05) and the relative weights of liver and brain were markedly elevated in the male rats in the middle and high dose groups (P〈0.05 or P〈0.01). The relative weights of kidney in the males in the high dose group were elevated (P 〈 0.01 ). Conclusions Fluazifop - P - butyl TC does not show mutagenicity. It may have some cumulative toxicity and the main target organs are brain, liver and kidney. Under the experimental condi- tions of this study, the noobservable - adverse - effect levels (NOVELs) of fluazifop - P - butyl TC in the subchronic oral toxicity test for the female and male rats are 6.8 mg/kg'd and 8.4 mg/kg'd, respectively.
出处 《实用预防医学》 CAS 2013年第2期232-233,226,共3页 Practical Preventive Medicine
关键词 精吡氟禾草灵原药 致突变性 亚慢性毒性 Fluazifop - P - butyl TC Mutagenicity Subchronic toxicity
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参考文献4

  • 1刘乾开 朱国念.新编农药使用手册[M].上海:上海科学技术出版社,1999.464. 被引量:26
  • 2GB15670-1995,农药登记毒理学试验方法[S].北京:国家技术监督局,1995.13-19. 被引量:9
  • 3李寿祺主编..毒理学原理与方法 第2版[M].成都:四川大学出版社,2003:433.
  • 4杨校华,顾刘金,陈秀凤,黄雅丽,徐娟,陈琼姜,孙建析,吴立仁,张幸.精吡氟禾草灵的亚慢性毒性研究[J].环境与职业医学,2007,24(5):526-528. 被引量:1

二级参考文献2

  • 1刘乾开 朱国念.新编农药使用手册[M].上海:上海科学技术出版社,1999.464. 被引量:26
  • 2国家技术监督局.GB15670-1995农药登记毒理学试验方法[S].北京:中国标准出版社,1995. 被引量:9

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