摘要
目的探讨血清转化生长因子β1(TGFβ1)与2型糖尿病周围神经病变(DPN)的关系。方法纳入38例健康体检者和85例2型糖尿病患者(T2DM组)。根据多伦多评分系统将85例T2DM患者按照有无周围神经病变及病变严重程度分为单纯T2DM组(A组,20例)、轻度DPN组(B1组,22例)、中度DPN组(B2组,22例)、重度DPN组(B3组,21例),分别测定TGFβ1含量,并收集受检者糖化血红蛋白、血脂、肾功能、尿微量白蛋白定量等临床资料,比较健康对照组和糖尿病各组TGFβ1水平及其他生化指标的差异。结果 T2DM患者TGFβ1水平显著高于健康对照组[(22.3±1.6)pg/mlvs.(17.4±0.2)pg/ml,P<0.01];DPN组TGFβ1水平较非DPN组升高[(22.1±1.8)pg/ml vs.(21.2±0.3)pg/ml,P<0.05];随着DPN严重程度的增加,血清TGFβ1的水平逐渐下降,差异有统计学意义(P<0.01);Logistic回归显示病程与DPN显著相关(P<0.01)。结论血清TGFβ1水平升高可能有助于DPN的早期诊断,病程是DPN的独立危险因素。
Objective To investigate the relationship between transforming growth factor beta 1 （TGFβ1） and peripheral neuropathy in patients with type 2 diabetes （DPN）. Methods According to Toronto rating system, 85 Type 2 diabetic mellitus （T2DM） patients were graded into A, B1, B2, and B3 stages based on the severity. The serum levels of TGFβ1, glycosylated hemoglobin （HbAlc） and lipids, as well as renal function were detected and analyzed among the different groups. Results Serum levels of TGF[31 were higher in total diabetes groups than in control group [（22.3±1.6） pg/ml vs. （17.4±0.2） pg/ml, P 〈 0.01]. Serum levels of TGFβ1 were higher in patients with DPN than patients without DPN [（22.1±1.8）pg/ml vs. （21.2±0.3） pg/ml, P 〈 0.05]. With the increase of DPN severity, the serum levels of TGFβ1 dropped （P 〈 0.01）. In a Logistic regression model, taking DPN as a dependent variable, the duration of diabetes was significantly associated with the severity of DPN （P 〈 0.01）. Conclusion High serum levels of TGFβ1 may be useful for the early diagnosis of DPN, and the duration of diabetes may be a risk factor for the development of peripheral neuropathy in T2DM patients.
出处
《北京医学》
CAS
2013年第2期99-102,共4页
Beijing Medical Journal
