摘要
生长素是一种多功能肽类激素,有多种生物学作用,对于生长素的研究已经开展了十几年了,除了通过其受体(GHS-R)介导生长激素的释放,生长素也参与了一系列的生物学功能,包括调节食物摄入量、睡眠、体重、血糖和胰岛素的代谢、肠胃蠕动、心血管功能、细胞增殖、炎性细胞因子等,最近发现,在男性和女性生殖系统的相关细胞及鱼类、鸟类和哺乳动物的生殖细胞,都有生长素和其受体的表达。本文主要阐述生长素可通过下丘脑-垂体-性腺轴影响生殖。
Ghrelin is a multifunctional peptide hormone that affects several biological functions,which was firstly studied about more than ten years.In addition to mediating GH release through the growth hormone secretagogue receptor（GHS-R）,ghrelin is involved in a series of biological functions including regulation of food intake,sleep,body weight,metabolism of glucose and insulin,gastrointestinal motility,cardiovascular functions,cell proliferation,production of proinflammatory cytokines et al.Recently reported that ghrelin and GHS-R1a are expressed in key cells of both male and female reproductive organs,and in several species including fishes,birds,and mammals.The objective of this paper was to report the funtion of ghrelin at the level of the hypothalamic-pituitary-gonadal axis that influencing reproduction.
出处
《中国优生与遗传杂志》
2013年第1期1-2,74,共3页
Chinese Journal of Birth Health & Heredity
关键词
生长素
生殖
Ghrelin
Reproduction
