摘要
目的:调查伊犁州0～14岁儿童先天性心脏病(congenital heart disease,CHD)的分布情况,揭示与CHD发生有关的环境和遗传危险因素,为CHD的预防提供相关指导。方法:根据现有442例CHD患儿,并从伊犁州8县1市随机抽取884例儿童,采用2∶1配对病例对照研究方法,并采用单因素及多因素Logistic回归分析进行CHD的危险因素分析。结果:最终筛选出8个与CHD发生相关的主要危险因素。结论:怀孕早期是胎儿心脏发育的关键阶段,环境和遗传因素在CHD的发生中扮演了重要的角色,CHD的病因学研究对减少CHD的发生具有重要的意义。避免有害环境因素的接触和加强孕期保健有益于减少CHD的发生。
Objective：To investigate the distribution of congenital heart disease（CHD）in children aged 0～14 years in Yili state.With the exploration possible environmental and genetic risk factors relevant to the occurrence of CHD.This study provided scientific guidelines for the prevention of CHD.Methods：In this population-based 2 ∶1 matched case-control study,442 children from eight counties and one city in Yili state were diagnosed as CHD,and 884 children from same districts were sampled randomly as the control group.Observation,heart auscultation and echocardiography examination were performed in the children.Single-factor analysis and multi-factors Logistic regression analysis were applied to analyze the risk factors of CHD.Results：Based on the single-factor analysis and multi-conditional Logistic regression model,eight risk factors related with the incidence of CHD were figured out.Conclusion：The early stage of pregnancy is the critical period for fetal cardiac development.Environmental and genetic factors played important roles in the occurrence of CHD.The etiologic research had great significance for diminishing the prevalence of CHD.Avoiding the exposure of environmental risk factors and strengthening pregnant care were beneficial to reduce the development of CHD.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2013年第1期78-82,共5页
Journal of Nanjing Medical University(Natural Sciences)
