摘要
目的探讨频域三维相干光学断层扫描(3D-OCT)测量中央角膜厚度(CCT)的准确性及可重复性。方法分别用3D-OCT、Orbscan-Ⅱ及超声角膜测厚仪测量近视患者265例(530眼)的CCT,对测量结果进行随机分组设计的方差分析及LSD检验,通过对三者测量值间差异检验3D-OCT测量CCT的准确性;用相关分析方法分析三者间相关性;并同时随机选取50例(100眼)近视患者用3D-OCT重复测量3次用类内相关系数(ICCs)检验可重复性。结果 3D-OCT、Orbscan-Ⅱ及超声角膜测厚仪测得的CCT均值分别为(538.78±23.83)μm、(537.51±39.15)μm、(554.09±37.31)μm。3D-OCT与Orbscan-Ⅱ测量CCT值间差异无统计学意义(P=0.245),两者均小于超声角膜测厚仪测得的CCT值,且差异有统计学意义(P值均<0.001)。3D-OCT、Orbscan-Ⅱ及超声角膜测厚仪三种仪器测量CCT值间有良好的相关性(r1,2=0.866、r2,3=0.806、r1,3=0.800,均P<0.001),并且3D-OCT具有很好的可重复性(ICCs=0.905)。结论由于3D-OCT对CCT测量与超声角膜测厚仪测量值之间较好的相关性及测量值的可重复性,因此可以将3D-OCT作为临床上一种非接触式CCT的测量方法。
Objective To investigate the accuracy and the repeatability of three dimensional frequency domain coherent optical tomography （3D - OCT） which measured central corneal thickness （CCT）. Methods The CCT of 530 eyes from 265 patients with myopiawere measured by 3D -OCT,Orbscan- Ⅱ and Ultrasound pachymetry,respectively. The data was analyzed by using the variance a nalysis of randomized block design,the least- significant difference （LSD） and correlation methods. CCT of 100 eyes from 50 patients were selected randomly measured three times by 3 D - OCT, and the variance of repeated measurements of 3 D - OCT was analyzed by u- sing Intraclass Correlation Coefficients （ICCs）. Results The average CCT measured by 3 D - OCT, Orbscan - Ⅱ , and Ultrasound pachy- metry were （538.78 ± 23.83 ） μm, （537.51 ± 39.15 ） μm and （ 554.09 ±37.31 ） μm, respectively. The CCT which measured by 3 D - OCT and Orbscan - Ⅱ were both thinner than Ultrasound pachymetry （P 〈 0.001 ）. There were good correlation among 3D - OCT, Orb- scan - Ⅱ and ultrasonic pachymetry （ r1,2 = 0. 866, r2.3 = 0. 806, rt,3 = 0. 800, P 〈 0.001 ）. Also 3D - OCT showed well repeatability （ ICCs = 0.905）. Conclusion 3 D - OCT could be anDlied to measure CCT as a kind of non - contact method.
出处
《宁夏医学杂志》
CAS
2013年第1期9-11,共3页
Ningxia Medical Journal
基金
宁夏医科大学校级特殊人才基金资助项目(XT201014)
