摘要
目的了解近4年医院耐甲氧西林葡萄球菌的分布,动态观察其分离率发展及耐药性,为临床合理应用抗菌药物提供依据。方法采用回顾性方法统计分析2007-2010年耐甲氧西林葡萄球菌的分布及耐药性。结果 4年共收集1349株葡萄球菌属,其中耐甲氧西林葡萄球菌775株,分离率为57.45%;连续4年耐甲氧西林葡萄球菌对青霉素、磺胺甲噁唑/甲氧苄啶耐药率>88.0%,对红霉素耐药率分别为60.24%、59.55%、63.31%、59.65%;克林霉素耐药率分别为36.36%、33.71%、40.70%、47.21%,对左氧氟沙星、夫西地酸、米诺环素耐药率较低,未发现耐万古霉素葡萄球菌。结论加强耐甲氧西林葡萄球菌连续规范的耐药监测,对临床调整治疗方案、有效控制医院感染的发生十分重要。
OBJECTIVE To learn the distribution of meticilin-resistant Staphylococcus in the recent four years,dynamically observe its development of isolation rate and the drug resistance so as to provide basis for the reasonable use of antibiotics.METHODS By means of the retrospective survey,the statistical analysis was performed for the distribution and drug resistance of the mehticilin-resistant Staphylococcus in 2007-2010.RESULTS There were totally 1349 strains of Staphylococci isolated within the four years,of which there were 775（57.45%） strains of meticilin-resistant Staphylococcus.The drug resistance rates of the methicillin-resistant Staphylococcus to penicillin and sulfamethoxazole/trimethoprim were higher than 88.0% during the four consecutive years,the drug resistance rates to erythromycin were 60.24%,59.55%,63.31%,and 59.65%,respectively,the drug resistance rates to clindamycin were 36.36%,33.71%,40.70%,and 47.21%,respectively,and the drug resistance rates to levofloxacin,fusidic acid,and minocycline were relatively low,there were no strains of vancomycin-resistant Staphylococcus isolated.CONCLUSION It is of great significance in adjusting the treatment program and controlling the nosocomial infections to strengthen the continuous and standard monitoring of drug resistance of methicillin-resistant Staphylococcus.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第3期670-672,共3页
Chinese Journal of Nosocomiology
关键词
耐甲氧西林葡萄球菌
药敏试验
耐药性
Meticilin-resistant Staphylococcus
Drug susceptibility testing
Drug resistance
