摘要
为研究胆木水提取物中的化学成分,利用D101大孔树脂、硅胶和自动纯化系统等各种色谱手段对其水提取物进行分离和纯化,共得到9个化合物,根据化合物的理化性质和波谱数据鉴定化学结构,它们分别是:naucleamide G(1)、3,4-dimethoxyphenol-β-D-apiofuranosyl(1→6)-β-D-glucopyranoside(2)、kelampayoside A(3)、3α,5α-tetrahydrodeoxycordifoline lactam(4)、naucleamide A-10-O-β-D-glucopyranoside(5)、短小蛇根草苷(6)、3-表短小舌根草苷(7)、异长春花苷内酰胺(8)及喜果苷(9)。化合物1为新化合物,化合物2为首次从该属植物中分离得到,化合物3和4为首次从该植物中分离得到。
In order to study the chemical constituents in the water extract of the stem of Nauclea officinalis, column chromatography over D101 macroporous resin and silica gel and an automatic purification system were used to isolate and purify the chemical constituents from the extract. Nine compounds were obtained. By analysis of the physicochemical properties and spectral data, their structures were identified as naucleamide G （1）, 3, 4-dimethoxyphenol-β-D-apiofuranosyl （1→6）-β-D-glucopyranoside （2）, kelampayoside A （3）, 3α, 5α- tetrahydrodeoxycordifoline lactam （4）, naucleamide A-10-O-β-D-glucopyranoside （5）, pumiloside （6）, 3-epi- pumiloside （7）, strictosamide （8） and vincosamide （9）, separately. Among them, compound 1 is a new compound, compound 2 was found in plants of the genus Nauclea for the first time, and compounds 3 and 4 were isolated from this plant for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
2013年第2期276-280,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81203001)
