摘要
目的:探讨甲基强的松龙冲击疗法治疗特发性脱髓鞘视神经病变的远期疗效。方法:对2003-01/2005-12在我院确诊为特发性脱髓鞘视神经病变患者81例104眼进行回顾性分析,随机分为A组和B组。A组采用甲基强的松龙冲击辅助营养神经及扩血管药物治疗,B组仅采用营养神经及扩血管药物治疗,观察两组患者首次发病后1,2,5a的视力、视野、视觉诱发电位的变化及复发率等。结果:各观察时间点两组患者视力提高、视野改善、视觉诱发电位恢复,差异无统计学意义(P>0.05);自发病初5a内A组患者复发率较B组明显降低,差异有统计学意义(P<0.05)。结论:甲基强的松龙冲击疗法能有效降低特发性脱髓鞘视神经病变患者的复发率。
AIM： To determine the long - term effect of methylprednisolone＇s shock therapy in idiopathic demyelinated optic neuropathy. METHODS： The data of 81 cases （104 eyes） diagnosed with idiopathic demyelinated optic neuropathy were retrospectively analyzed. The cases were divided into group A and group B. Group A were applied methylprednisolone to aid in trophic nerve and expansion blood vessels＇ drug therapy, group B were applied only trophic nerve and expansion blood vessels＇ drug therapy. The two group＇s eyesight, visual field and visual evoked potential＇s change and recurrence rate were observed after 1 year, 2, 5 years respectively. RESULTS： There was no significant difference of eyesight improvement, vision improvement and visual evoked potential recovery between two groups at each observation time point（P〉0.05）. From the beginning of this disease till five years, group A＇s recurrence rate was been much lower than group B, There was statistical significant difference（P〈0.05）, CONCLUSION ： The methylprednisolone＇s shock therapy can reduce the recurrence of the patients.
出处
《国际眼科杂志》
CAS
2013年第2期322-323,共2页
International Eye Science
关键词
激素冲击疗法
特发性脱髓鞘视神经病变
远期疗效
hormone shock therapy
idiopathic demyelinated optic neuropathy
long-term effect
