摘要
目的研究镇痫丸药物的长期毒性。方法将大鼠随机分为两组,给药组灌胃给药,对照组同体积的常水灌胃,在3、6个月及恢复期,各组分别进行血常规、肝肾功能和主要脏器病理检查。结果各组动物在给药期间和恢复期未出现毒性反应和死亡现象,各给药组动物体征、血常规、肝功能、肾功能和主要脏器病理检查与对照组比较,差异均无统计学意义(P>0.05)。结论通过3～6个月的动物试验观察,镇痫丸对动物机体无损害现象发生及毒性反应,为临床用药安全提供了可靠的依据,值得临床进一步观察使用。
Objective To research the long-term toxicity of the Zhenxian pill. Methods Mice was randomly divided into two groups, the drug was given intragastrically to the drug group, while ordinary water with the same dose was given to the control group. In 3rd month, 6th month and the recovery phase, pathological examinations on blood routine, liver and kidney function and major internal organs were carried out on both groups. Results Animals in each group did not appear toxic reaction or die during the experimental phase and the recovery phase. Pathological examination observations, including animal physical signs, blood routine, functions of liver, kidney and major organs, showed no significant difference between drug group and control group （P 0.05）. Conclusion Through 3 to 6 months′ experiment and observation, no damage or toxic reaction are found after taking Zhenxian pill. This provided reliable foundations on the clinical safe administration. Zhenxian pill is worthy of further observation or use.
出处
《中国当代医药》
2013年第2期5-6,共2页
China Modern Medicine
关键词
镇痫丸
癫痫
血常规
肝肾功能
Zhenxian pill
Epilepsy
Blood routine
Liver and kidney function
