摘要
目的:比较黄体中期长方案垂体降调节中应用重组人黄体生成激素(r-hLH,Luveris)与人绝经期促性腺激素(HMG)对体外受精-胚胎移植(IVF-ET)结局的影响。方法:选取2011年2月—11月行IVF/卵胞浆内单精子注射(ICSI)-ET治疗的正常促性腺激素(Gn)水平患者281例,对其临床资料进行回顾性分析。根据加用外源性LH的不同分为HMG组和r-hLH组。其中HMG组共100个周期,r-hLH组共181个周期。比较2组在获卵数、受精率、优胚率、人绒毛膜促性腺激素(hCG)日内膜厚度、中重度卵巢过度刺激综合征(OHSS)发生率和临床妊娠率等方面的差异。结果:HMG组总Gn刺激时间少于r-hLH组(P=0.049),前者hCG日雌二醇(E2)水平高于r-hLH组(P=0.033);HMG组OHSS发生率高于r-hLH组(P=0.016);HMG组受精率高于r-hLH组(P=0.000)。2组在Gn总量、hCG日内膜厚度、获卵数、正常受精率、种植率、优良胚胎形成率以及临床妊娠率方面差异均无统计学意义(P>0.05)。结论:与HMG相比,r-hLH可能具有更为安全的妊娠结局。
Objective：To compare IVF outcomes of the controlled ovarian stimulation （COS） protocols with r-FSH plus recombinant LH （Luveris） versus r-FSH plus HMG （Le BaoDe）. Methods：The outcomes of 281 infertile normogonadotropic patients undergoing IVF/ICSI treatment were retrospectively analyzed from Feburary to November in 2011 in our center. Patients were divided into two groups according to the addition of different exogenous luteinizing hormone preparation in COS ：the HMC group （n=100） and the r-hLH group （n= 181）. Numbers of oocytes retrieved and fertilized,and the high quality embryos rate,as well as thickness of endometrium on the day of hCG administration,incidence of OHSS and clinical pregnancy rate,were compared as the main parameters of outcomes. Results： Duration of ovarian stimulation of the HMG group was shorter than that of the r-hLH group （P=0.049）. The mean level of serum E2 on the day of hCG administration of the HMG group was statistically higher than that of the r-hLH group（P=0.033）. The incidence of OHSS in the HMG group was much higher than that in the r-hLH group （P=0.016）. Higher fertilization rate was found in the HMG group （P=0.000）. There existed no significant differences between two groups in the total FSH consumption,thickness of endometrium on the day of hCG administration,the number of ooeytes retrieved, embryo cleaved rate,high quality embryos rate,implantation rate and clinical pregnancy rate （P 〉0.05）. Conclusions：Compared with HMG,r-hLH may lead to better IVF outcomes in safety and efficiency,and lower risk of OHSS.
出处
《国际生殖健康／计划生育杂志》
CAS
2013年第1期5-8,共4页
Journal of International Reproductive Health/Family Planning
关键词
促性腺素类
促黄体激素
受精
体外
胚胎移植
妊娠结局
Gonadotropins
Luteinizing hormone
Fertilization in vitro
Embryo transfer
Pregnancy outcome
