摘要
目的评价选择性肝动脉栓塞化疗术(TACE)联合经皮无水乙醇注射(PEI)治疗少血供肝癌的临床效果。方法收集经肝穿刺活检、螺旋CT增强及数字减影血管造影机检查为少血供肝癌患者40例的临床资料进行回顾性分析。20例仅行TACE治疗为TACE组,20例行TACE联合PEI治疗为TACE+PEI组,比较2组患者治疗有效率、甲胎蛋白转阴率及术后1、2年生存率。结果TACE+PEI组和TACE组治疗有效率分别为85%(17/20)和55%(11/20),甲胎蛋白转阴率分别为85%(17/20)和50%(10/20),术后1年生存率分别为95%(19/20)和75%(17/20),术后2年生存率分别为70%(14/20)和35%(7/20)。2组患者治疗有效率、甲胎蛋白转阴率及术后2年生存率比较,差异均有统计学意义(均P〈0.05)。结论TACE联合PEI治疗少血供肝癌安全有效。
Objective To evaluate the clinical efficacy of the combination of transarterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) in treating hypovascular liver cancer. Methods Forty patients who were diagnosed of hypovascular liver cancer were divided into two groups: group TACE + PEI (20 cases) which under-went TACE and PEI; group TACE (20 cases) which underwent only TACE. The rates of effectiveness, the transnegative rates of alpha fetal protein (AFP) and the 1 and 2 years survival rates of the two groups were compared. Results The rates of effectiveness in the TACE + PEI group and TACE group was 85% (17/20) and 55% ( 11/20), The transformation rates of AFP were 85% (17/20) and 50% (10/20). The 1, 2 years survival rates was 95% ( 19/ 20) and 75% (17/20), 70% (14/20) and 35% (7/20), respectively. There were significant differences in the rates of effectiveness, the transformation rates of AFP and the 2 years survival rates between both groups ( all P 〈 0.05 ). Conclusion Combination of TACE and PEI is a safe and effective treatment for hypovascular liver cancer.
出处
《中国医药》
2013年第2期189-190,共2页
China Medicine
基金
江苏省分子和功能影像重点实验室开放研究基金(PYZX2011017)
关键词
肝肿瘤
肝动脉栓塞化疗术
无水乙醇注射术
Liver neoplasms
Transarterial chemoembolization
Percutaneous ethanol injection liver neoplasms