摘要
目的观察思密达混合液联合还原型谷胱甘肽保留灌肠治疗放射性直肠炎的临床疗效。方法选择我院2005年—2011年收治的放射性直肠炎患者共45例,将患者按就诊序号分为对照组23例和试验组22例。两组患者均加强支持治疗,进食高营养无渣饮食,积极防治便秘,保持大便通畅。对照组采用思密达混合液在便后或睡前进行保留灌肠,1次/d,2周为1个疗程;试验组在对照组基础上加用还原型谷胱甘肽1.2 g。观察并记录两组患者治疗1个疗程后的临床疗效及治疗期间出现的不良反应。结果对照组治愈3例,好转7例,无效13例;试验组治愈6例,好转12例,无效4例,两组临床疗效间差异有统计学意义(u=150.00,P<0.05)。治疗期间对照组有2例、试验组有1例患者出现下腹部阵发性绞痛并伴有恶心。结论思密达混合液联合还原型谷胱甘肽保留灌肠治疗放射性直肠炎疗效确切,安全可行,值得临床推广应用。
Objective To evaluate the effectiveness of retention enema with combination of smectite mixed liquid and reduced glutathione in treating radiation proctitis （RP）. Methods A total of 45 RP patients were randomly divided into intervention group （ n = 23 ） and control group （ n = 22 ）. All patients were provided with liquid nourishment support during the preparation period. Then the control group were treated by retention enema with smectite mixed liquid （ after defeeation or before sleep; once daily, every two weeks） , whereas the intervention group was further treated by reduced glutathione （ 1.2 g） in addition to the treatment in the control group. The effectiveness and adverse reactions were evaluated after two weeks. Results In the control group, 3 patients were cured, 7 improved, and 13 failed after the 2 -week treatment; In the intervention group, on the contrary, 6 eured, 12 improved, and 4 failed （u = 150. 00, P 〈0.05）. Two patients in the control group and one in the intervention group experienced paroxysmal cramps at the lower abdomen and nausea during the treatment. Concluions Retention enema with combination of smectite mixed liquid and reduced glutathione is safe and effective for treating RP patients.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第2期208-209,共2页
Chinese General Practice
