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可溶性endoslin及可溶性血管内皮生长因子受体-1的表达与早发型子痫前期的关系 被引量:16

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摘要 目的:检测可溶性endoslin(sEng)及可溶性血管内皮生长因子受体-1(sFIt-1)在血清及胎盘中的表达,探讨两者的关系及其在早发型子痫前期发病中的作用。方法:(1)用酶联免疫吸附法(ELISA)检测45例早发型子痫前期患者(早发型子痫前期组,其中轻度30例、重度15例)及20例正常晚期妊娠孕妇(对照组)的血清中sEng及sFIt-1的水平。(2)用免疫组化方法检测两组孕妇胎盘组织中sEng及sFIt-1的表达。结果:(1)早发型子痫前期组血清及胎盘组织中sEng及sFIt-1水平均明显高于对照组(均P<0.01)。(2)早发型子痫前期组患者血清及胎盘组织中sEng水平分别与相应部位的sFIt-1水平呈正相关(r=0.376,P<0.05;r=0.425,P<0.05)。结论:孕妇血清及胎盘组织中sEng、sFIt-1水平变化与子痫前期发病及病情发展有关。
出处 《实用医学杂志》 CAS 北大核心 2013年第3期442-443,共2页 The Journal of Practical Medicine
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参考文献5

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