摘要
目的探讨大剂量甲基强的松龙冲击治疗对原发性脑干损伤转归的影响。方法回顾性比较和分析了观察组46例早期应用大剂量甲基强的松龙冲击治疗和对照组65例未进行激素治疗的原发性脑干损伤患者的转归，对死亡患者记录死亡时间；对生存患者分别于伤后1周和6个月进行GCS评分，同时于伤后6个月进行GOS、语言及运动障碍程度评分。结果与对照组比较，早期应用大剂量甲基强的松龙冲击治疗的患者死亡率明显下降，死亡患者生存时间明显延长；生存患者神经功能恢复速度明显加快，恢复程度明显提高。结论早期大剂量甲基强的松龙冲击治疗可以明显提高原发性脑干损伤患者生存率，并改善其预后。
Objective To study the therapeutic effect of high dose methylprednisolone on primary brain stem injury. Methods The therapeutic effects were retrospectively compared and analyzed between 46 patients given high dose methylprednisolone therapy at the early stage and 65 patients without hormonotherapy in control group. The survival time of the dead was recorded, and the Glasgow Coma Scale （GCS） was graded one week and 6 months respectively after injury, and the Glasgow Outcome Scale （ GOS）, language barrier and motor function barrier degree evaluation were conducted at the same time 6 months later. The effects were observed and compared with a parallel control test. Results Compared with the control group, in the patients given high dose methylprednisolone therapy at the early stage, the mortality decreased and the survival time of the dead prolonged markedly, while the central nervous function of the survivals recovered more rapidly and completely. Conclusion High dose methylprednisolone therapy at the early stage can increase the survival rate of the primary brain stem injuries and improve the patients＇prognosis significantly.
出处
《中国急救医学》
CAS
CSCD
北大核心
2013年第1期36-38,共3页
Chinese Journal of Critical Care Medicine
基金
基金项目：国家杰出青年基金项目（30125020）
