摘要
目的探讨代谢综合征(metabolic syndrome,MS)患者胰岛素抵抗及血浆醛固酮(aldosterone,ALD)水平的关系.方法 79例MS患者,根据MS不同组合成份分为MS合并2型糖尿病及高血压组(MS1组,31例)、MS合并2型糖尿病组(MS2组,28例)、MS合并高血压组(MS3组,20例).所有受试对象均行3 h口服葡萄糖耐量试验及卧立位醛固酮试验,以稳态模型公式计算胰岛素抵抗指数(HOMA IR).结果 MS各亚组血ALD、胰岛素曲线下面积(INSAUC)、HOMA-IR及HOMA-IR≥2.18者所占比例高于对照组(P<0.05).MS1组血ALD、胰岛素曲线下面积(INSAUC)、HOMA-IR及HOMA-IR≥2.18者所占比例高于MS2组及MS3组,差异有显著性(P<0.05).MS2组血ALD、胰岛素曲线下面积(INSAUC)、HOMA-IR及HOMA-IR≥2.18者所占比例略高于MS3组,但差异无统计学意义(P>0.05).Pearson相关分析显示,血浆醛固酮与BMI、WC、TG、FPG、FINS、HOMA-IR、DBP呈正相关,与HDL-C呈负相关.多元回归分析表明,HOMA-IR是MS患者血浆醛固酮水平的独立影响因素(β=0.12,P<0.05).结论 MS患者血浆醛固酮水平增高,增高的醛固酮与HOMA-IR和MS大部分组分相关.
Objective To analyse the relationship of plasma aldosterone and insulin resistance and its syndrome （MS）. Methods 79 metabolic syndrome patients were components in patients with the metabolic divided into three groups according to the different components of MS： 31 patients with type 2 diabetes mellitus and hypertension （MS1 group） , 28 patients with type 2 diabetes mellitus （MS2 group） and 20 patients with hypertension （MS3 group）. 20 normal subjects served as controls. All patients were given 3 h oral glucose tolerance test and orizontal and vertical position of aldosterone test, HOMA-insulin resistance index （HOMA-IR） was calculated by Homeostasis Model. Results Plasma aldosterone, the insulin area under curve （INSAUC） , HOMA-IR and prevalence of insulin resistance were significantly higher in the clustering of MS components than control group （P 〈 0.05 ）. These indexes were significantly higher in MS1 than MS2 and MS3 group in the clustering of MS components （P 〈 0.05）. These indexes were higher in MS2 group than in MS3 group, but there was no significant difference （P 〉 0.05）. Pearson correlation analysis showed that plasma aldosterone was positively correlated with body mass index （BMI）, waist circumference （WC）, triglyceride （TG）, fasting （FPG）, fasting insulin （FINS） , HOMA-IR and diastolic blood pressure （DBP） （r = 0.562, 0.502, P〈0.01; r=0.394, P〈0.01; r=0.225 , P〈0.01; r=0.586, P〈0.01; r=0.385 , 0.299 , P〈 0.01）, negatively correlated with high density lipoprotein cholesterol （HDL-C） （r = plasma glucose P 〈 0.01; r= P〈 0.01; r= -0.298 , P〈0.01 ）. The multiple regression analysis showed that HOMA-IR was an independent factor of plasma aldosterone level in patients with the metabolic syndrome （ β = 0.12, P 〈 0.05）. Gonclusion The increasing of plasma aldosterone in patients with the metabolic syndrome may be related with IHOMA-IR and some components of MS.
出处
《昆明医科大学学报》
CAS
2012年第12期102-106,共5页
Journal of Kunming Medical University
关键词
代谢综合征
胰岛素抵抗
醛固酮
Metabolic syndrome
Insulin resistance
Aldosterone
