摘要
目的探讨ESR1基因XbaⅠ遗传多态性与乳腺增生症的相关性。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析技术,分别检测89例乳腺增生症患者(研究组)和35例健康体检者(对照组)ESR1基因XbaⅠ遗传多态性。结果 ESR1基因XbaI位点的基因型及等位基因频率在研究组和对照组中的分布差异有统计学意义(P<0.05)。等位基因频率的相对风险分析,X等位基因患乳腺增生症的风险是x等位基因的0.551倍。结论 ESR1基因XbaⅠ遗传多态性与乳腺增生症的发病有关,突变基因增加了乳腺增生症发病风险。
Objective To investigate the relationship between estrogen receptor - α（ ESRI ） gene Xba Ⅰ polymorphisms and breast hyperplasia. Methods PCR-RFLP was used to investigate the ESR1 gene Xba I polymorphisms between breast hyper- plasia patients（ study group, n =89 ） and healthy controls （ control group, n = 35 ）. Results The difference between the study group and control group in the genotypic and allele frequency of the ESRI gene Xbal wfis statistically significant （ P 〈 0. 05 ）. According to analyze of the odds ratio （OR） for X allele was 0. 551 times to x allele. Conclusion The polymorphisms of Xba I of ESR1 gene has relationship with breast, hyperplasia and the mutant gene increased breast hyperplasia mod）idity risk.
出处
《四川医学》
CAS
2012年第12期2041-2043,共3页
Sichuan Medical Journal
基金
四川省卫生厅科研项目(编号:090534)
关键词
乳腺增生症
雌激素受体
基因多态性
breast hyperplasia
estrogen receptor
gene polymorphism
