摘要
目的探讨糖化白蛋白(GA)在肝硬化患者中的变化及其临床意义。方法采用酶法测定105例肝硬化患者及80名健康体检者血清中糖化白蛋白分值(GA%),同时采用己糖激酶法(HK)测定血糖(Glu)。根据Child-Pugh标准对105例肝硬化患者进行分级,其中A级86例,B+C级19例。比较GA%及Glu在各组中的差异。结果肝硬化组GA%水平及异常率明显高于正常对照组(P<0.01),而Glu水平及异常率2组间差异无统计学意义(P>0.05)。随着肝病病情的发展,GA%异常率明显上升;而Glu无明显差异。结论 GA%在血糖正常的肝硬化患者中异常增高,且与病情的发展密切相关。
Objective To investigate the clinical significance and change of glycated albumin（GA） for patients with liver cirrhosis.Methods The percentage of GA（GA%） and the level of glucose（Glu） in 105 patients with liver cirrhosis and 80 healthy controls were detected by enzyme method and hexokinase（HK） method.A total of 105 patients with liver cirrhosis were classified into 2 groups according to the Child-Pugh criterion,86 patients in Child-Pugh A group and 19 patients in Child-Pugh B＋C group.The differences of GA% and Glu between the 2 groups were analyzed.Results GA% increased significantly in liver cirrhosis group,compared with that in control group（P0.01）.There was no statistical significance of the level and abnormal rate of Glu between the 2 groups（P0.05）.Furthermore,along with the progression of liver disease,the abnormal rate of GA% increased obviously,and that of Glu had no significant difference.Conclusions GA% in liver cirrhosis patients with normal Glu increases abnormally and is closely related to the disease progression.
出处
《检验医学》
CAS
2012年第11期948-950,共3页
Laboratory Medicine
关键词
糖化白蛋白
血糖
肝硬化
Glycated albumin
Glucose
Liver cirrhosis
