摘要
11β-羟基类固醇脱氢酶(11β-HSD)是糖皮质激素的代谢酶,该酶分为11β-HSD1与11β-HSD2两种亚型。11β-HSD1使无活性的可的松转化为有活性的氢化可的松,参与了肥胖、高血脂、高血糖、高血压等代谢综合征的病理生理过程。另外,高水平的糖皮质激素暴露与神经系统功能紊乱及年龄相关性认知功能障碍有关。11β-HSD2通过使糖皮质激素失活起到保护盐皮质激素受体的作用。反之,11β-HSD2基因缺陷或突变会导致高盐皮质激素综合征,表现为水钠潴留、高血压、低血钾。通过对11β-HSD的功能及其作用机制的深入研究,为代谢综合征及其相关疾病提供了新的治疗方法。
11β-hydroxysteroid dehydrogenase（ 11β-HSD） catalyses the conversion of inactive to active glucocorticoids. Two isozymes have been discovered, each with unique properties and powerful biological roles. 11β-HSD1 converts inactive cortisone to active cortisol. Excessive glucocorticoid exposure causes obesity ,hyperlipidemia, hyperglycemia, hypertension, which are collectively called metabolic syndrome. Moreover, high levels of giucocorticoids can cause neuropsychiatric dysfunction and cognitive impairments. 11β-HSD2 prevents the stimulation of mineralocorticoid receptor by converting active cortisol to inactive cortisone. Conversely, 11β-HSD2 gene defect or mutation can cause high mineral corticoid syndrome such as sodium reabsorption, hypertension and hypokalemia. More detailed discussion of 11β-HSD will provide novel therapeutic target for metabolic disease and many other related diseases.
出处
《医学综述》
2013年第1期40-42,共3页
Medical Recapitulate
