摘要
目的食管小细胞恶性肿瘤是食管癌中肿瘤形态学相似的一系列肿瘤,主要包括小细胞癌、淋巴瘤、低分化鳞状细胞癌及低分化腺癌等。由于其组织来源及分子表达的不同,其临床生物学行为及治疗方法截然不同,因此,要明确诊断小细胞癌、淋巴瘤、低分化鳞状细胞癌及低分化腺癌。方法收集61例食管小细胞恶性肿瘤患者的临床资料,分析临床病理资料、形态学特征,进行免疫组化Ki-67、CD 56、TTF-1、CgA、8yn、P 63、CK 5/6、LCA、CK 1 8的染色。结果 61例中小细胞癌56例,低分化鳞状细胞癌3例,腺鳞癌1例,混合性腺神经内分泌癌1例。结论食管小细胞癌、低分化鳞状细胞癌、腺鳞癌、混合性腺神经内分泌癌及淋巴瘤等小细胞恶性肿瘤治疗方法不同,应充分利用免疫组化进行正确诊断和鉴别诊断,从而可以减少误诊误治,规避医疗风险。
Objective Esophagus small cell malignant carcinoma have the resemble morphology, which include the small cell carcinoma, lymphoma, poorly differentiated squamous cell carcinoma and adenocarcinoma, and so on. They have different biological behaviors and therapy methods because of their different histology origin and molecule expression, so it is important for doctors and patient to diagnose correctly esophagus small cell malignant carcinoma. Methods We collected 61 cases of esophagus small cell malignant carcinoma, then analysised clinical pathology data and morphology character and stained by immunochemistry for Ki-67、CD 56、TTF-1、CgA、Syn、P 63、CK 5/6、LCA、CK 18. Results For the 61 cases, we diagnosed 56 cases to the esophagus small cell carcinoma, 3 cases to the poorly differentiated squamous carcinoma,1 case adenosquamous carcinoma and 1 case mixed adennoneuroendocrine carcinoma according to IHC stain. Conclusion The small cell carcinoma, poorly differentiated squamous cell carcinoma,adenosquamous carcinoma,Mixed Adenoneuroendocrine Carcinoma and lymphoma have different therapy methods, we should identify their diagnosis and differential diagnosis with IHC thoroughly, and decrease incidence of misdiagnosis and mistreatment.
出处
《当代医学》
2013年第4期16-19,共4页
Contemporary Medicine
关键词
食管肿瘤
小细胞恶性肿瘤
食管小细胞癌
Esophagus carcinoma
Ssmall cell malignant carcinoma
Esophagus small cell carcinoma
