摘要
目的:探讨Pim-3和MCM7蛋白在人肺腺癌组织中的表达及其临床意义。方法:采用免疫组化En-Vision法检测30例人正常肺组织和60例人肺腺癌组织中Pim-3和MCM7蛋白的表达,分析二者与临床病理特征之间的关系。结果:60例肺腺癌组织中Pim-3和MCM7蛋白的阳性表达均显著高于正常组(P<0.001,P<0.001),肺腺癌组中Pim-3和MCM7蛋白的阳性表达均与原发肿瘤的大小、组织学分级、淋巴结转移及TNM分期有关(P<0.02),而与患者的年龄、性别无关(P>0.05)。Pim-3与MCM7蛋白的表达水平呈显著正相关(r=0.786,P<0.01)。结论:Pim-3和MCM7蛋白的协同表达可能涉及了肺腺癌的发生、发展过程,Pim-3激酶可能是肺腺癌分子靶向药物治疗的新靶标。
Objective：To study the expression and clinical significance of Pim -3 and MCM7 protein in human lung adenocarcinoma tissues. Methods： The expression of Pim - 3 and MCM7 protein were examined by immunohisto- chemistry in 30 cases of normal lung tissues and 60 cases of lung adenocareinoma tissues. The relationship between expression levels and phathological characters was analyzed. Results： The positive expression of Pim - 3 and MCM7 protein in lung adenocarcinoma group were significantly higher than those in normal lung tissues group （P 〈 0. 001, P 〈 0. 001 ）, respectively. The overexpresssion of Pim - 3 and MCM7 protein in lung adenocareinoma were significantly correlated with the size of primary tumor, histological grading, lymph node metastasis and clinical TNM staging（P 〈 0.02 ） , but no relationship with age and gender（ P 〉 0.05 ） , Pim- 3 and MCM7 were significantly and direety cor- related with each other in lung adenoearcinoma （ r = 0. 786, P 〈0. 01 ）. Conclusion ： The overexpression of Pim - 3 and MCM7 protein may play an important role in the earcinognesis and progression of lung adenoearcinoma. The Pim -3 kinase may become a potential target of gene therapy to lung adenocareinoma.
出处
《现代肿瘤医学》
CAS
2013年第1期69-72,共4页
Journal of Modern Oncology
基金
广西自然科学基金资助项目(编号:桂科自0991270)
