摘要
目的:了解广西出生缺陷医院监测网神经管缺陷(NTDs)变化趋势及影响因素,为政府决策提供依据。方法:按照中国出生缺陷监测方案的要求,对2006～2011年的41所出生缺陷医院监测点的神经管缺陷资料进行流行病学分析,将在医疗保健机构住院分娩的孕28周至产后7天的围产儿作为监测对象。结果:6年间共监测的围产儿有484 304人,其中NTDs为231例,NTDs总发生率4.77/万,年度发生率呈逐年下降趋势,降幅达64.57%。其中无脑畸形、脊柱裂、脑膨出发生率分别是2.44/万、1.67/万、0.66/万。围产儿NTDs的发生率男性为4.60/万,女性为4.75/万。城镇为2.45/万,乡村为6.52/万;产妇年龄别发生率的差异有统计学意义,<20岁组发生率最高(11.04/万)。产前确诊的比例74.46%,产前B型超声波诊断的比例为77.06%。结论:2006～2011年广西围产儿NTDs的发生率出现下降趋势,农村育龄妇女是NTDs干预的重点人群。
Objective： To understand the change trend and influencing factors of Neural Tube Defects （NTDs） of Guangxi Birth Defect Surveillance Network, and provide evidence for governmelats to make decisions. Methods： An epidemiologieal analysis on the data of neural tube defects in 41 birth defect surveillance hospitals from 2006 to 2011 in accordance with the requirements of China Birth Defect Sur- veillance Scheme. Surveillance subjects were the perinatal infants from 28 gestational weeks to 7 days after birth in healtheare institutions. Results： There were 484 304 perinatal infants under surveillance from 2006 to 2011, and 231 cases were found with NTDs, the incidence rate was 4. 77/10 000. The annual incidence rate decreased gradually by 64.57%. The incidence rates of anencephaly, spina bifi- da, and encephalocele were 2. 44/10 000, 1.67/10 000, and 0. 66/10 000, respectively. The perinatal incidence rates of NTDs were 4. 60/ 10 000 in males and 4. 75/10 000 in females, 2. 45/10 000 in urban areas and 6. 52/10 000 in rural areas. There was statistically significant difference in maternal incidence rate for age, and the incidence rate in 〈 20 -year -old children was the highest （11.04/10 000） . The prenatal diagnostic rate and prenatal B -type ultrasonic diagnostic rate were 77.46% and 77.06%, respectively. Conclusion： The inci- dence of perinatal NTDs showed a decreasing trend in Guangxi from 2006 to 2011, and women of childbearing age in rural areas are the focus group of intervention.
出处
《中国妇幼保健》
CAS
北大核心
2013年第1期151-154,共4页
Maternal and Child Health Care of China
基金
广西科学研究与技术开发计划课题〔桂科攻1140003B-81〕
关键词
神经管缺陷
叶酸
围产儿
监测
产前诊断
Neural tube defects
Folic acid
Perinatal infant
Surveillance
Prenatal diagnosis
