摘要
实验采用大鼠背根节慢性压迫动物模型 ,记录术后3 -10天背根节的自发放电 ,在156根纤维中观察到17根 (11 % )出现的动作电位峰峰间期以某一基础间期的整数倍出现的时间节律形式 ,其回归映射图为晶格状点阵结构。同时观察到Na+ 通道特异阻断剂TTX和K+ 通道阻断剂4 -AP能对整数倍放电节律产生影响。结果表明 :看似不规则的整数倍放电时间序列是有着内在的结构和规律性的 ,它由膜上通道和环境的状态决定。建立针对本实验的动力学模型 ,改变对应于实验的相应参数 ,可以重现实验现象。整数倍节律的发生可能是由于模型中阈下混沌吸引子和阈上吸引子的共存机制。因此 ,确定性动力学机制可以引发整数倍节律。
We investigated the spontaneous discharge of dorsal root ganglion (DRG) neurons of rat undergone 3-10 days chronic compression. It was found that the interspike interval (ISI) of 17 out of 156 fibers have integer multiples temporal rhythm pattern, in which all the ISI are integer multiples of a basic ISI and a return map of their ISI can be constructed as a crystal grid structure. This temporal pattern could be modified by Na+ channel and K+ channel of their neuron membrane. Data indicated that some irregular discharge trains have their intrinsic regularity. All these phenomenon can be simulate from a neuron dynamic model involving sodium current, potassium current, T-type calcium current, sag current, persistent sodium current, ‘A' current, leak current and applied current.
出处
《生物物理学报》
CAS
CSCD
北大核心
2000年第2期250-258,共9页
Acta Biophysica Sinica
基金
国家自然科学基金!(基金号 :39740029)资助项目
关键词
自发放电
神经元放电模型
整数部节律
动力学
Spontaneous discharge
Neuron discharge model
Integer multiples rhythm
Neural information coding
Chaos attractor
