摘要
目的:探讨COX-2与PTEN及E-cadherin在食管癌组织中的表达及意义,以期了解三者在食管癌发生、发展及转移中的相互作用。方法:采用免疫组化法分别检测COX-2、PTEN、E-cadherin在60例食管癌组织中的表达情况及相互关系。结果:COX-2在食管癌组织中的表达为70.00%,明显高于在正常食管鳞状上皮中的表达(P<0.01)。而PTEN及E-cadherin在食管癌中表达分别为43.33%和38.33%,明显低于两者正常食管组织中的阳性率(P<0.01)。在食管癌中COX-2表达与PTEN、E-cadherin的表达及分化程度呈一定的负相关,而与淋巴结转移呈正相关。而PTEN及E-cadherin的表达与淋巴结转移呈负相关。结论:COX-2、PTEN及E-cadherin共同参与食管癌的发生且影响癌细胞转移;食管癌中COX-2与PTEN及E-cadherin的表达呈负相关性;联合检测COX-2、PTEN及E-cadherin有望成为食管癌早期诊断、评估生物学行为及预后的重要指标。
Objective To investigate the expression of COX-2,PTEN and E-cadherin in the esophageal carcinoma and to explore their interactions.Method The expression of COX-2,PTEN and E-cadherin was evaluated in 60 cases with esophageal carcinoma by immunohistochemical staining methods.Results The positive rate of COX-2 was 70.00%,which was significantly higher in esophageal carcinoma than that in normal squamous cell of esophagus（P0.01）.The positive rate of PTEN and of E-cadherin was 43.33% and 38.33% respectively,which was significantly weaker in esophageal carcinoma than that in normal squamous cell of esophagus（P0.01）.The expression of COX-2 was negatively correlated with PTEN,E-cadherin and differentiating degree.But it was positively correlated with the lymph-node metastasis.The expression of PTEN and E-cadherin was negatively correlated with the lymph-node metastasis.Conclusion COX-2,PTEN and E-cadherin may play an important role in esophageal carcinoma development and lymph node metastasis.The expression of COX-2 is negatively correlated with PTEN and E-cadherin in esophageal carcinoma.There may be an interaction action among COX-2,PTEN and E-cadherin.Expressions of COX-2,PTEN and E-cadherin may be helpful in early diagnosis and evaluation of the biological behavior and prognosis of esophageal carcinoma.
出处
《吉林医学》
CAS
2013年第1期10-13,共4页
Jilin Medical Journal
基金
重庆市卫生局医学科技项目[项目编号:2010-2-433]
