摘要
目的:比较膀胱癌患者及正常人尿液及血液中微量元素钙、镁含量的差异,研究膀胱癌相关危险因素。方法:选取76例膀胱癌患者为膀胱癌组和80名正常人为对照组,采集血清和尿液标本,并进行问卷调查。通过火焰原子吸收光谱法检测两组样本尿液及血清中的钙、镁元素。采用独立样本t检验比较两组的差异,问卷资料中相关危险因素用Logistic回归分析。结果:正常人组血清中的钙含量高于膀胱癌组(P=0.002),尿液中的钙和镁含量均低于膀胱癌组,P值分别为0.005和0.039,问卷调查提示服用非甾体抗炎药、吸烟和长期不良憋尿习惯是膀胱癌的危险因素,P值分别为0.000、0.004和0.000。结论:钙镁离子的代谢失衡和膀胱癌的发生发展有一定的相关性,服用非甾体抗炎药、吸烟和长期不良憋尿习惯在膀胱癌发生发展中是一危险因素。
OBJECTIVE： To discuss the variation of the trace elements-magnesium and calcium in bladder cancer and control group,and research correlative factors of bladder cancer. METHODS： Seventy-six patients with bladder cancer chosen as a study group and 80 healthy volunteers chosen as a control group were all assayed for urinary and serum trace elements using an atomic absorption spectrophotometer, and the results were analyzed by independent sample vtests. The correlative factors were determined by logistic regression analysis. RESULTS： There was a significant increase in mean calcium serum level in control group compared to bladder cancer patients （P=0. 002）. In contrast,urine levels of control group were significantly lower （P were 0. 005 and 0. 039） than those of study group. Smoke was the significant risk factor of bladder cancer（P were 0. 000,0. 004 and 0. 000）. CONCLUSIONS：The metabolic disorder of calcium and magnesium might have an important role in bladder cancer occurrence and development. Smoking is the risk factor of bladder cancer.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第22期1748-1750,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
辽宁省科学技术计划(2010225032)
关键词
膀胱肿瘤
尿液
血清
镁
钙
bladder neoplasms
urine
serum
magnesium
calcium
